EP 0889889 B1 20060920 - PIPERAZINE AND PIPERIDINE COMPOUNDS
Title (en)
PIPERAZINE AND PIPERIDINE COMPOUNDS
Title (de)
PIPERAZIN- UND PIPERIDIN- DERIVATE
Title (fr)
COMPOSES DE PIPERAZINE ET PIPERIDINE
Publication
Application
Priority
- EP 97908288 A 19970320
- EP 9701461 W 19970320
- EP 96200864 A 19960329
Abstract (en)
[origin: WO9736893A1] The invention relates to a group of new piperazine and piperidine compounds having interesting pharmacological properties. It has been found that compounds of formula (a) wherein A represents a heterocyclic group of 5-7 ring atoms wherein 1-3 heteroatoms from the group O, N and S are present; R1 is hydrogen or fluoro; R2 is C1-4-alkyl, C1-4-alkoxy or an oxo group, and p is 0, 1 or 2; Z represents carbon or nitrogen, and the dotted line is a single bond when Z is nitrogen, and a single or double bond when Z is carbon; R3 and R4 independently are hydrogen or C1-4-alkyl; n has the value 1 or 2; R5 is halogen, hydroxy, C1-4-alkoxy or C1-4-alkyl, and q is 0, 1, 2 or 3; Y is phenyl, furanyl or thienyl, which groups may be substituted with 1-3 substituents of the group hydroxy, halogen, C1-4-alkoxy, C1-4-alkyl, cyano, aminocarbonyl, mono- or di-C1-4-alkylaminocarbonyl; and salts thereof show high affinity for both the dopamine D2 and serotonin 5-HT1A receptors.
IPC 8 full level
C07D 405/04 (2006.01); A61K 31/00 (2006.01); A61K 31/34 (2006.01); A61K 31/343 (2006.01); A61K 31/357 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/44 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/535 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); A61K 31/5513 (2006.01); A61P 25/04 (2006.01); A61P 43/00 (2006.01); C07D 209/08 (2006.01); C07D 215/12 (2006.01); C07D 215/38 (2006.01); C07D 263/58 (2006.01); C07D 265/36 (2006.01); C07D 307/79 (2006.01); C07D 311/18 (2006.01); C07D 317/66 (2006.01); C07D 319/08 (2006.01); C07D 319/14 (2006.01); C07D 319/18 (2006.01); C07D 321/10 (2006.01); C07D 327/06 (2006.01); C07D 333/54 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 407/10 (2006.01); C07D 407/12 (2006.01); C07D 409/04 (2006.01); C07D 409/10 (2006.01); C07D 409/12 (2006.01); C07D 411/04 (2006.01); C07D 413/04 (2006.01); C07D 413/10 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP US)
A61P 25/00 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/18 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 209/08 (2013.01 - EP US); C07D 215/12 (2013.01 - EP US); C07D 263/58 (2013.01 - EP US); C07D 265/36 (2013.01 - EP US); C07D 307/79 (2013.01 - EP US); C07D 311/18 (2013.01 - EP US); C07D 317/66 (2013.01 - EP US); C07D 319/08 (2013.01 - EP US); C07D 319/18 (2013.01 - EP US); C07D 321/10 (2013.01 - EP US); C07D 327/06 (2013.01 - EP US); C07D 333/54 (2013.01 - EP US); C07D 405/04 (2013.01 - EP US); C07D 407/10 (2013.01 - EP US); C07D 409/10 (2013.01 - EP US); C07D 413/10 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9736893 A1 19971009; AT E340173 T1 20061015; AU 2029497 A 19971022; AU 708053 B2 19990729; BR 9708389 A 20000104; BR 9708389 B1 20091201; BR PI9708389 B8 20151208; CA 2250347 A1 19971009; CA 2250347 C 20060221; CN 1100055 C 20030129; CN 1215400 A 19990428; CZ 294413 B6 20041215; CZ 306898 A3 19990113; DE 69736704 D1 20061102; DE 69736704 T2 20070913; DK 0889889 T3 20070129; EP 0889889 A1 19990113; EP 0889889 B1 20060920; ES 2271967 T3 20070416; HU 227454 B1 20110628; HU P9902471 A2 20000328; HU P9902471 A3 20000428; IL 126187 A0 19990509; JP 2000507949 A 20000627; JP 3989554 B2 20071010; NO 320970 B1 20060220; NO 984533 D0 19980928; NO 984533 L 19981102; NZ 331860 A 20000428; PL 189256 B1 20050729; PL 329123 A1 19990315; PT 889889 E 20070131; RU 2178414 C2 20020120; SK 133198 A3 19990211; SK 285119 B6 20060601; TR 199801942 T2 20000821; TW 422846 B 20010221; UA 52656 C2 20030115; US 6225312 B1 20010501; ZA 972639 B 19971002
DOCDB simple family (application)
EP 9701461 W 19970320; AT 97908288 T 19970320; AU 2029497 A 19970320; BR 9708389 A 19970320; CA 2250347 A 19970320; CN 97193520 A 19970320; CZ 306898 A 19970320; DE 69736704 T 19970320; DK 97908288 T 19970320; EP 97908288 A 19970320; ES 97908288 T 19970320; HU P9902471 A 19970320; IL 12618797 A 19970320; JP 53488697 A 19970320; NO 984533 A 19980928; NZ 33186097 A 19970320; PL 32912397 A 19970320; PT 97908288 T 19970320; RU 98119523 A 19970320; SK 133198 A 19970320; TR 9801942 T 19970320; TW 86104056 A 19970328; UA 98105745 A 19970320; US 15560899 A 19990304; ZA 972639 A 19970326