EP 0892791 A1 19990127 - SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS
Title (en)
SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS
Title (de)
SUBSTITUIERTE BENZENESULFONAMIDE DERIVATE ALS PRODROGEN VON COX-2 INHIBITOREN
Title (fr)
DERIVES BENZENESULFONAMIDE SUBSTITUE UTILISABLES COMME PRECURSEURS DES INHIBITEURS DU COX-2
Publication
Application
Priority
- US 9705497 W 19970411
- US 63151496 A 19960412
Abstract (en)
[origin: WO9738986A1] Prodrugs of COX-2 inhibitors of formula (I) are described as being useful in treating inflammation and inflammation-related disorders wherein A is a ring substituent selected from partially unsaturated heterocyclyl, heteroaryl, cycloalkenyl and aryl, wherein A is optionally substituted at a substitutable position with one or more radicals selected from alkylcarbonyl, formyl, halo, alkyl, haloalkyl, oxo, cyano, nitro, carboxyl, alkoxy, aminocarbonyl, alkoxycarbonyl, carboxyalkyl, cyanoalkyl, hydroxyalkyl, haloalkylsulfonyloxy, alkoxyalkyloxyalkyl, carboxyalkoxyalkyl, cycloalkylalkyl, alkenyl, alkynyl, heterocyclyloxy, alkylthio, cycloalkyl, aryl, heterocyclyl, cycloalkenyl, aralkyl, heterocyclylalkyl, alkylthioalkyl, arylcarbonyl, aralkylcarbonyl, aralkenyl, alkoxyalkyl, arylthioalkyl, aryloxyalkyl, aralkylthioalkyl, aralkoxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, alkylaminocarbonyl, N-arylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, alkylaminocarbonylalkyl, alkylamino, N-arylamino, N-aralkylamino, N-alkyl-N-aralkylamino, N-alkyl-N-arylamino, aminoalkyl, alkylaminoalkyl, N-arylaminoalkyl, N-aralkylaminoalkyl, N-alkyl-N-aralkylaminoalkyl, N-alkyl-N-arylaminoalkyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylsulfinyl, alkylsulfonyl, aminosulfonyl, alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, and N-alkyl-N-arylaminosulfonyl; wherein R<1> is selected from heterocyclyl, cycloalkyl, cycloalkenyl and aryl, wherein R<1> is optionally substituted at a substitutable position with one or more radicals selected from alkyl, haloalkyl, cyano, carboxyl, alkoxycarbonyl, hydroxyl, hydroxyalkyl, haloalkoxy, amino, alkylamino, arylamino, nitro, alkoxyalkyl, alkylsulfinyl, halo, alkoxy and alkylthio; wherein R<2> is selected from hydrido and alkoxycarbonylalkyl; and wherein R<3> is selected from alkyl, carboxyalkyl, acyl, alkoxycarbonyl, heteroarylcarbonyl, alkoxycarbonylalkylcarbonyl, alkoxycarbonylcarbonyl, amino acid residue, and alkylcarbonylaminoalkylcarbonyl; provided A is not tetrazolium, or pyridinum; and further provided A is not indanone when R<3> is alkyl or carboxyalkyl; or a pharmaceutically-acceptable salt thereof.
IPC 1-7
C07D 261/08; C07D 233/54; C07D 401/04; A61K 31/42; A61K 31/415; C07D 231/12; C07D 495/04; C07D 263/32; C07C 311/39; C07D 207/32; C07D 307/58
IPC 8 full level
C07D 233/64 (2006.01); A61K 31/00 (2006.01); A61K 31/18 (2006.01); A61K 31/34 (2006.01); A61K 31/341 (2006.01); A61K 31/365 (2006.01); A61K 31/40 (2006.01); A61K 31/415 (2006.01); A61K 31/4162 (2006.01); A61K 31/4164 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/635 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 5/16 (2006.01); A61P 7/06 (2006.01); A61P 9/10 (2006.01); A61P 11/02 (2006.01); A61P 11/06 (2006.01); A61P 11/08 (2006.01); A61P 13/12 (2006.01); A61P 15/06 (2006.01); A61P 17/02 (2006.01); A61P 17/04 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 21/00 (2006.01); A61P 21/04 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 27/12 (2006.01); A61P 29/00 (2006.01); A61P 29/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07C 311/16 (2006.01); C07C 311/39 (2006.01); C07C 311/51 (2006.01); C07D 207/32 (2006.01); C07D 207/327 (2006.01); C07D 207/33 (2006.01); C07D 231/12 (2006.01); C07D 233/54 (2006.01); C07D 233/62 (2006.01); C07D 261/08 (2006.01); C07D 263/32 (2006.01); C07D 307/46 (2006.01); C07D 307/58 (2006.01); C07D 401/04 (2006.01); C07D 417/04 (2006.01); C07D 495/04 (2006.01)
IPC 8 main group level
C07D (2006.01)
CPC (source: EP KR US)
A61K 31/18 (2013.01 - EP US); A61K 31/415 (2013.01 - EP US); A61K 31/42 (2013.01 - EP KR US); A61K 31/635 (2013.01 - EP US); A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/16 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/02 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 11/08 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/06 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 17/04 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 23/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/04 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/12 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 29/02 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 311/16 (2013.01 - EP US); C07C 311/39 (2013.01 - KR); C07C 311/51 (2013.01 - EP US); C07D 207/33 (2013.01 - EP US); C07D 231/12 (2013.01 - EP US); C07D 233/64 (2013.01 - EP US); C07D 261/08 (2013.01 - EP KR US); C07D 263/32 (2013.01 - EP US); C07D 307/58 (2013.01 - EP US); C07D 401/04 (2013.01 - EP US); C07D 417/04 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US); C07C 2601/10 (2017.04 - EP US)
Citation (search report)
See references of WO 9738986A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9738986 A1 19971023; AP 1009 A 20010921; AP 9801355 A0 19981231; AT E233743 T1 20030315; AT E408607 T1 20081015; AU 2722797 A 19971107; AU 734275 B2 20010607; AU 734275 C 20060914; BG 102916 A 19990831; BG 109057 A 20051031; BG 64531 B1 20050630; BR 1100403 A 20000725; BR 9708574 A 19990803; CA 2249009 A1 19971023; CA 2249009 C 20030916; CN 1098256 C 20030108; CN 1216043 A 19990505; CU 23116 A3 20060329; CZ 271098 A3 19990113; CZ 297430 B6 20061213; DE 69719496 D1 20030410; DE 69719496 T2 20040408; DE 69739003 D1 20081030; DK 0892791 T3 20030623; DK 1288206 T3 20081124; EA 003319 B1 20030424; EA 199800919 A1 19990429; EE 03685 B1 20020415; EE 9800351 A 19990415; EP 0892791 A1 19990127; EP 0892791 B1 20030305; EP 1288206 A1 20030305; EP 1288206 B1 20080917; ES 2194195 T3 20031116; ES 2311571 T3 20090216; GE P20032998 B 20030625; HK 1019741 A1 20000225; HU 225473 B1 20061228; HU P9901807 A2 19990928; HU P9901807 A3 20000828; IL 125849 A0 19990411; IL 125849 A 20031031; IL 153738 A0 20030706; IL 153738 A 20071031; IS 2156 B 20061115; IS 4863 A 19981009; IS 7292 A 20040602; JP 2000509029 A 20000718; JP 2003160554 A 20030603; JP 3382624 B2 20030304; JP 4049307 B2 20080220; KR 100387658 B1 20030819; KR 20000005395 A 20000125; LT 4586 B 19991227; LT 98142 A 19990726; LV 12239 A 19990320; LV 12239 B 19990820; ME 00768 B 20111010; NO 314184 B1 20030210; NO 984727 D0 19981009; NO 984727 L 19981214; NZ 331542 A 19990729; OA 11015 A 20030312; PL 195955 B1 20071130; PL 329276 A1 19990315; PT 1288206 E 20081114; PT 892791 E 20030630; RO 121338 B1 20070330; RS 50019 B 20080929; SI 22713 A 20090831; SI 22713 B 20091231; SI 9720035 A 19990630; SI 9720035 B 20091031; SK 124298 A3 19990413; SK 285353 B6 20061103; TR 199802049 T2 19990118; TW 585857 B 20040501; UA 47475 C2 20020715; US 2003069287 A1 20030410; US 2005032851 A1 20050210; US 5932598 A 19990803; US 6436967 B1 20020820; US 6815460 B2 20041109; US 7420061 B2 20080902; YU 44398 A 19991227; ZA 973146 B 19980414
DOCDB simple family (application)
US 9705497 W 19970411; AP 9801355 A 19970411; AT 02025005 T 19970411; AT 97921092 T 19970411; AU 2722797 A 19970411; BG 10291698 A 19981112; BG 10905798 A 19981112; BR 1100403 A 19970502; BR 9708574 A 19970411; CA 2249009 A 19970411; CN 97193747 A 19970411; CU 1998147 A 19981012; CZ 271098 A 19970411; DE 69719496 T 19970411; DE 69739003 T 19970411; DK 02025005 T 19970411; DK 97921092 T 19970411; EA 199800919 A 19970411; EE 9800351 A 19970411; EP 02025005 A 19970411; EP 97921092 A 19970411; ES 02025005 T 19970411; ES 97921092 T 19970411; GE AP1997004523 A 19970411; HK 99104900 A 19991101; HU P9901807 A 19970411; IL 12584997 A 19970411; IL 15373802 A 20021230; IL 15373897 A 19970411; IS 4863 A 19981009; IS 7292 A 20040602; JP 2002258955 A 20020904; JP 53713997 A 19970411; KR 19980708126 A 19981012; LT 98142 A 19981009; LV 980215 A 19981012; ME P1998443 A 19970411; NO 984727 A 19981009; NZ 33154297 A 19970411; OA 9800193 A 19981012; PL 32927697 A 19970411; PT 02025005 T 19970411; PT 97921092 T 19970411; RO 9801469 A 19970411; SI 9720035 A 19970411; SI 9720101 A 19970411; SK 124298 A 19970411; TR 9802049 T 19970411; TW 86107093 A 19970526; UA 98115994 A 19970411; US 17869702 A 20020624; US 561098 A 19980112; US 66185900 A 20000914; US 93985204 A 20040913; YU 44398 A 19971009; ZA 973146 A 19970414