EP 0892807 A1 19990127 - GENE FAMILY ASSOCIATED WITH NEUROSENSORY DEFECTS
Title (en)
GENE FAMILY ASSOCIATED WITH NEUROSENSORY DEFECTS
Title (de)
MIT NEUROSENSORISCHEN DEFEKTEN VERKNÜPFTE GENFAMILIE
Title (fr)
FAMILLE GENETIQUE ASSOCIEE A DES DEFICIENCES NEURO-SENSORIELLES
Publication
Application
Priority
- US 9705903 W 19970410
- US 63059296 A 19960410
- US 70138096 A 19960822
- US 70629296 A 19960904
- US 71499196 A 19960917
Abstract (en)
[origin: WO9738004A1] Nucleic acid compositions are provided that encode a family of mammalian proteins expressed in the retina and brain. Members of the gene family are genetically linked to various neurosensory defects, including cochlear degeneration, peripheral retinal degeneration and cone-rod retinal dystrophy. The nucleic acid compositions find use in identifying DNA sequences encoding homologous or related proteins; for production of the encoded protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of neurosensory defects, identification of retinal cells based on expression, and the like. The DNA is further used as a diagnostic for genetic predisposition to the linked neurosensory defect.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A01K 67/027 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 27/00 (2006.01); A61P 27/02 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/00 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 27/00 (2017.12); A61P 27/02 (2017.12); C07K 14/47 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9738004A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9738004 A1 19971016; AU 2450797 A 19971029; CA 2251603 A1 19971016; EP 0892807 A1 19990127; JP 2000509255 A 20000725
DOCDB simple family (application)
US 9705903 W 19970410; AU 2450797 A 19970410; CA 2251603 A 19970410; EP 97920276 A 19970410; JP 53647297 A 19970410