EP 0893990 A1 19990203 - OPHTHALMOLOGICAL COMPOSITION OF THE TYPE WHICH UNDERGOES LIQUID-GEL PHASE TRANSITION
Title (en)
OPHTHALMOLOGICAL COMPOSITION OF THE TYPE WHICH UNDERGOES LIQUID-GEL PHASE TRANSITION
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNG VOM FLÜSSIG/GEL-PHASENÜBERGANGSTYP
Title (fr)
COMPOSITION OPHTALMOLOGIQUE SUBISSANT UNE TRANSITION DE PHASE LIQUIDE/GEL
Publication
Application
Priority
- EP 9701285 W 19970312
- FR 9603142 A 19960313
- US 1334396 P 19960313
Abstract (en)
[origin: WO9733562A1] The present invention relates to an ophthalmological composition intended for contacting with the lacrimal fluid wherein said composition is intended to be administered as a non-gelled liquid form and is intended to gel in situ, this composition containing at least one polysaccharide in aqueous solution, of the type which undergoes liquid-gel phase transition gelling in situ under the effect of an increase in the ionic strength of said lacrimal fluid and a pharmaceutically active substance characterised in that said pharmaceutically active substance is pilocarpine or a pharmaceutically acceptable salt thereof, wherein said composition comprises a first component which is an acid aqueous solution of pilocarpine and a second component which is a neutral or alkaline aqueous solution of a polysaccharide of the type which undergoes liquid-gel phase transition under the effect of an increase in the ionic strength, said components being mixed extemporaneously at the time of first use.
IPC 1-7
IPC 8 full level
A61K 9/08 (2006.01); A61K 9/00 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 47/36 (2006.01)
CPC (source: EP)
A61K 9/0048 (2013.01)
Citation (search report)
See references of WO 9733562A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9733562 A1 19970918; AU 2287597 A 19971001; CA 2248881 A1 19970918; EP 0893990 A1 19990203; JP 2000506182 A 20000523
DOCDB simple family (application)
EP 9701285 W 19970312; AU 2287597 A 19970312; CA 2248881 A 19970312; EP 97915364 A 19970312; JP 53229697 A 19970312