EP 0894137 A1 19990203 - NOVEL HUMAN MYELOID TERMINAL DIFFERENTIATION RESPONSE GENE
Title (en)
NOVEL HUMAN MYELOID TERMINAL DIFFERENTIATION RESPONSE GENE
Title (de)
MENSCHLICHES GEN, WELSCHES IN RAHMEN DER MYELOIDEN ZELLDIFFERENZIERUNG AKTIVERT WIRD
Title (fr)
NOUVEAU GENE DE REPONSE A LA DIFFERENCIATION TERMINALE MYELOIDE D'ORIGINE HUMAINE
Publication
Application
Priority
- US 9702458 W 19970214
- US 60220896 A 19960215
Abstract (en)
[origin: CA2246578A1] The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for MYD118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 polypeptide. The invention specifically provides for use of the MYD118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide and amino acid sequences for MYD118. The invention further provides antibodies which specifically bind to MYD118.
IPC 1-7
C12N 15/19; C12N 15/11; C12N 15/85; C12N 5/10; C12Q 1/68; C07K 16/24; A61K 38/19; A61K 48/00; G01N 33/53; C07K 14/47
IPC 8 full level
G01N 33/50 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 48/00 (2006.01); A61P 7/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); C12N 5/06 (2006.01); C12N 5/08 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/12 (2006.01); C12N 15/19 (2006.01); C12N 15/85 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01)
Citation (search report)
See references of WO 9730157A1
Designated contracting state (EPC)
BE DE ES FR GB IT NL
DOCDB simple family (publication)
AU 1960797 A 19970902; CA 2246578 A1 19970821; EP 0894137 A1 19990203; JP 2000517163 A 20001226; MX 9806628 A 19981231
DOCDB simple family (application)
AU 1960797 A 19970214; CA 2246578 A 19970214; EP 97907656 A 19970214; JP 52955197 A 19970214; MX 9806628 A 19980814