EP 0896543 A1 19990217 - DRUG FOR THE TREATMENT OF TUMOURS CONTAINING INHIBITORS FOR TGF-BETA AND INHIBITORS OF RAS-ACTIVATION
Title (en)
DRUG FOR THE TREATMENT OF TUMOURS CONTAINING INHIBITORS FOR TGF-BETA AND INHIBITORS OF RAS-ACTIVATION
Title (de)
ARZNEIMITTEL FÜR DIE BEHANDLUNG VON TUMORERKRANKUNGEN ENTHALTEND INHIBITOREN VON TGF-BETA UND INHIBITOREN DER RAS-AKTIVIERUNG
Title (fr)
MEDICAMENT POUR LE TRAITEMENT DE TUMEURS CONTENANT DES INHIBITEURS DE TGF-BETA ET DES INHIBITEURS POUR L'ACTIVATION DE RAS
Publication
Application
Priority
- DE 19613691 A 19960405
- EP 9701699 W 19970404
Abstract (en)
[origin: DE19613691A1] The invention concerns a drug containing as its active constituent a substance which inhibits the action of TGF beta on tumour cells of epithelial origin for the treatment of epithelial, invasive tumours characterized by a reversible transition of the cells from an epithelial, non-invasive state to a fibroblastic, invasive state. The drug contains a TGF beta inhibitor, preferably in combination with a Ras inhibitor. The invention also concerns a method of screening substances for the treatment of epithelial, invasive tumours.
IPC 1-7
IPC 8 full level
A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 13/12 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61K 38/179 (2013.01 - EP US); A61K 39/3955 (2013.01 - EP US); A61P 11/00 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP)
Citation (search report)
See references of WO 9737678A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19613691 A1 19971009; AU 2508597 A 19971029; CA 2250839 A1 19971016; EP 0896543 A1 19990217; JP 2000509024 A 20000718; US 2002127542 A1 20020912; US 6383733 B1 20020507; WO 9737678 A1 19971016
DOCDB simple family (application)
DE 19613691 A 19960405; AU 2508597 A 19970404; CA 2250839 A 19970404; EP 9701699 W 19970404; EP 97916436 A 19970404; JP 53583397 A 19970404; US 15571699 A 19990216; US 8607302 A 20020301