EP 0900081 A4 20020109 - INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (en)

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Title (de)

INHIBITOREN DER FARNESYL-PROTEIN TRANSFERASE

Title (fr)

INHIBITEURS DE FARNESYL-PROTEINE TRANSFERASE

Publication

EP 0900081 A4 20020109 (EN)

Application

EP 97917604 A 19970327

Priority

GB 9610338 A 19960517
US 9704750 W 19970327
US 1479296 P 19960403

Abstract (en)

[origin: WO9736591A1] The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

IPC 1-7

A61K 31/495; C07D 403/06; C07D 401/06

IPC 8 full level

A61K 31/496 (2006.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 13/12 (2017.12); A61P 25/00 (2017.12); A61P 27/02 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 401/06 (2013.01); C07D 403/06 (2013.01)

Citation (search report)

[X] US 4598079 A 19860701 - BEYERLE RUDI [DE], et al
[X] WO 9321186 A1 19931028 - FUJISAWA PHARMACEUTICAL CO [JP], et al
[X] US 5382584 A 19950117 - BALASUBRAMANIAN NEELAKANTAN [US]
[X] CA 983495 A 19760210 - SCIENCE UNION & CIE
[PX] WO 9630343 A1 19961003 - MERCK & CO INC [US], et al
[Y] WO 9500497 A1 19950105 - MERCK & CO INC [US], et al
[Y] EP 0670314 A1 19950906 - KYOWA HAKKO KOGYO KK [JP]
[PY] WO 9637204 A1 19961128 - MERCK & CO INC [US], et al
See references of WO 9736591A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9736591 A1 19971009; AU 2587997 A 19971022; AU 707347 B2 19990708; CA 2250587 A1 19971009; EP 0900081 A1 19990310; EP 0900081 A4 20020109; JP 2001518067 A 20011009

DOCDB simple family (application)

US 9704750 W 19970327; AU 2587997 A 19970327; CA 2250587 A 19970327; EP 97917604 A 19970327; JP 53535797 A 19970327