EP 0900199 A1 19990310 - AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS
Title (en)
AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS
Title (de)
AZETIDINONDERIVATE ZUR BEHANDLUNG VON ATHEROSKLEROSE
Title (fr)
DERIVES D'AZETIDINONE POUR LE TRAITEMENT DE L'ATHEROSCLEROSE
Publication
Application
Priority
- EP 9702286 W 19970428
- GB 9608649 A 19960426
Abstract (en)
[origin: WO9741099A1] Compounds of formula (I) in which inter alia X is a linker group A-B in which A is bond, CH2O, CO, CONR<6>, COO, CONR<6>CO, or CONR<6>O in which R<6> is hydrogen or C(1-6)alkyl and B is (CH2)pCO(CH2)q in which p is an integer from 1 to 8, preferably 3 to 5, and q is 0 or an integer from 1 to 8, preferably 0, 1 or 2, such that p + q = 1 to 12, preferably 5 to 8, more preferably 5; are inhibitors of the enzyme Lp PLA2 and therefore of use in therapy, in particular, treating atherosclerosis.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/395 (2006.01); A61K 31/397 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/04 (2006.01); A61P 29/00 (2006.01); A61P 39/00 (2006.01); A61P 39/06 (2006.01); A61P 43/00 (2006.01); C07D 205/08 (2006.01); C07D 205/09 (2006.01); C07D 205/095 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 17/00 (2017.12); A61P 17/06 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 25/04 (2017.12); A61P 29/00 (2017.12); A61P 39/00 (2017.12); A61P 39/06 (2017.12); A61P 43/00 (2017.12); C07D 205/08 (2013.01); C07D 205/09 (2013.01); C07D 205/095 (2013.01)
Citation (search report)
See references of WO 9741099A1
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9741099 A1 19971106; EP 0900199 A1 19990310; GB 9608649 D0 19960703; JP 2000509063 A 20000718
DOCDB simple family (application)
EP 9702286 W 19970428; EP 97921853 A 19970428; GB 9608649 A 19960426; JP 53860397 A 19970428