EP 0900214 B1 20010926 - PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES
Title (en)
PROCESS FOR PREPARATION OF PYRIMIDINE DERIVATIVES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON PYRIMIDIN-DERIVATEN
Title (fr)
PROCEDE DE PREPARATION DE DERIVES DE PYRIMIDINE
Publication
Application
Priority
- KR 9700073 W 19970430
- KR 19960014538 A 19960504
- KR 19960014539 A 19960504
- KR 19960049380 A 19961029
- KR 19960049381 A 19961029
- KR 19960049382 A 19961029
Abstract (en)
[origin: WO9742186A1] The present invention relates, first to a process for preparation of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine represented by formula (I) and its acid addition salts, second, to a process for preparation of an intermediate for preparing the compound (I), and, third, to a novel intermediate compound. More specifically, the present invention relates, first, to a process for preparation of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl,1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine represented by formula (I), and its acid addition salts by reacting a pyrimidine derivative represented by formula (II-A), in which Hal represents a halogen, with 1-methyl-1,2,3,4-tetrahydroisoquinoline represented by formula (III), second, to a process for preparating of the pyrimidine derivative of formula (II-A) and the compound of formula (III); and, third, to a novel intermediate compound including the pyrimidine derivative of formula (II-A).
IPC 1-7
IPC 8 full level
C07B 53/00 (2006.01); C07D 217/02 (2006.01); C07D 239/42 (2006.01); C07D 239/47 (2006.01); C07D 401/04 (2006.01); C07D 213/00 (2006.01); C07D 239/00 (2006.01)
CPC (source: EP US)
C07D 217/02 (2013.01 - EP US); C07D 239/42 (2013.01 - EP US); C07D 401/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9742186 A1 19971113; AT E206117 T1 20011015; AU 2713397 A 19971126; AU 712970 B2 19991118; CA 2253906 A1 19971113; CA 2253906 C 20020402; CA 2358479 A1 19971113; CA 2358479 C 20040713; CN 1097591 C 20030101; CN 1190427 C 20050223; CN 1217722 A 19990526; CN 1425655 A 20030625; DE 69706981 D1 20011031; DE 69706981 T2 20020606; DK 0900214 T3 20020128; EP 0900214 A1 19990310; EP 0900214 B1 20010926; ES 2165052 T3 20020301; HK 1019336 A1 20000203; JP 2001055379 A 20010227; JP 3160297 B2 20010425; JP H11509237 A 19990817; PT 900214 E 20020328; RU 2174978 C2 20011020; US 5990311 A 19991123
DOCDB simple family (application)
KR 9700073 W 19970430; AT 97920966 T 19970430; AU 2713397 A 19970430; CA 2253906 A 19970430; CA 2358479 A 19970430; CN 02124785 A 19970430; CN 97194367 A 19970430; DE 69706981 T 19970430; DK 97920966 T 19970430; EP 97920966 A 19970430; ES 97920966 T 19970430; HK 99104379 A 19991007; JP 2000198538 A 20000630; JP 53975697 A 19970430; PT 97920966 T 19970430; RU 98121687 A 19970430; US 17157998 A 19981021