Global Patent Index - EP 0904109 A4

EP 0904109 A4 2002-11-04 - TARGETING MACROMOLECULAR PRODRUGS TO T LYMPHOCYTES

Title (en)

TARGETING MACROMOLECULAR PRODRUGS TO T LYMPHOCYTES

Title (de)

GEGEN T-LYMPHOZYTEN ZIELGERICHTETE MAKROMOLEKULARE ARNZNEIMITTEL-VORSTUFEN

Title (fr)

PROMEDICAMENTS MACROMOLECULAIRE DE CIBLAGE DES LYMPHOCYTES T

Publication

EP 0904109 A4 (EN)

Application

EP 97915001 A

Priority

  • US 9703832 W
  • US 61669396 A

Abstract (en)

[origin: WO9733618A1] A composition for intracellular delivery of a chemical agent into a T cell comprises a receptor-binding and endocytosis-inducing ligand and a chemical agent coupled to a water soluble polymer. The ligand binds to a receptor on T lymphocytes and elicits endocytosis of the composition. The composition also includes a spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is a copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA). The composition can further comprise a carrier such as a water soluble polymer, liposome, or particulate. Methods of using these compositions for delivering a chemical agent in vivo or in vitro are also disclosed.

IPC 1-7 (main, further and additional classification)

A61K 39/395

IPC 8 full level (invention and additional information)

A61K 9/127 (2006.01); A61K 31/704 (2006.01); A61K 47/32 (2006.01); A61K 47/36 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01)

CPC (invention and additional information)

C07K 16/2896 (2013.01); A61K 47/6425 (2017.08); C07K 14/70596 (2013.01)

Citation (search report)

  • [A] WO 9004176 A1 19900419 - SCRIPPS CLINIC RES [US]
  • [Y] RIHOVA B ET AL: "SELECTIVITY OF ANTIBODY-TARGETED ANTHRACYCLINE ANTIBIOTICS ON T LYMPHOCYTES", JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, vol. 5, no. 3, 1990, pages 249 - 266, XP001106402, ISSN: 0883-9115
  • [Y] RIHOVA B: "BIOLOGICAL PROPERTIES OF TARGETABLE POLYUN-(I-HYDROXYPROPYL)- METHACRYLAMIDE-ANTIBODY CONJUGATES", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 2, 1985, pages 289 - 310, XP002910382, ISSN: 0168-3659
  • [YD] HEDRICK J ET AL: "INTERACTION BETWEEN EPSTEIN-BARR VIRUS AND A T CELL LINE HSB-2 VIA A RECEPTOR PHENOTYPICALLY DISTINCT FROM COMPLEMENT RECEPTOR TYPE 2", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 22, no. 5, 1992, pages 1123 - 1131, XP001106487, ISSN: 0014-2980
  • See also references of WO 9733618A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9733618 A1 19970918; AU 2205797 A 19971001; AU 708304 B2 19990729; BR 9711081 A 20000111; CA 2247432 A1 19970918; EP 0904109 A1 19990331; EP 0904109 A4 20021104; JP 2001519762 A 20011023; ZA 9702087 B 19971024

INPADOC legal status


2003-04-16 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20021101

2002-12-18 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20021104

2002-12-18 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 47/48 A, 7A 61P 35/00 B, 7A 61P 31/18 B

2002-11-04 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

2002-11-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

1999-03-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19980914

1999-03-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE