Global Patent Index - EP 0904398 A4

EP 0904398 A4 20041201 - CHEMOKINE ALPHA 3

Title (en)

CHEMOKINE ALPHA 3

Title (de)

CHEMOKIN ALPHA 3

Title (fr)

CHEMOKINE ALPHA 3

Publication

EP 0904398 A4 20041201 (EN)

Application

EP 96911336 A 19960318

Priority

  • CA 2249995 A 19960318
  • US 9603686 W 19960318

Abstract (en)

[origin: WO9735027A1] Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

IPC 1-7

C12N 15/19; C12N 1/20; C12Q 1/68; G01N 33/53; C07K 1/00; C07K 1/14; A61K 45/05; A61K 38/00; A61K 38/19; C07K 14/52

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/19 (2006.01); C07K 1/00 (2006.01); C07K 1/14 (2006.01); C07K 14/52 (2006.01); C12N 1/20 (2006.01); C12N 15/00 (2006.01); C12N 15/19 (2006.01); C12P 21/02 (2006.01); C12P 21/06 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); A61K 48/00 (2006.01)

CPC (source: EP)

C07K 14/522 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2799/026 (2013.01)

Citation (search report)

  • [X] WO 9412537 A2 19940609 - UNIV LEUVEN REGA INST [BE], et al
  • [X] PROOST P ET AL: "HUMAN AND BOVINE GRANULOCYTE CHEMOTACTIC PROTEIN-2: COMPLETE AMINO ACID SEQUENCE AND FUNCTIONAL CHARACTERIZATION AS CHEMOKINES", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 32, 1993, pages 10170 - 10177, XP002049871, ISSN: 0006-2960
  • [X] PROOST P ET AL: "IDENTIFICATION OF A NOVEL GRANULOCYTE CHEMOTACTIC PROTEIN (GCP-2) FROM HUMAN TUMOR CELLS", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 150, no. 3, 1 February 1993 (1993-02-01), pages 1000 - 1010, XP002061116, ISSN: 0022-1767
  • [X] POWER C A ET AL: "CLONING OF A FULL-LENGTH CDNA ENCODING THE NEUTROPHIL-ACTIVATING PEPTIDE ENA-78 FROM HUMAN PLATELETS", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 151, 1994, pages 333 - 334, XP002049873, ISSN: 0378-1119
  • [X] CHANG M-S ET AL: "CLONING AND CHARACTERIZATION OF THE HUMAN NEUTROPHIL-ACTIVATING PEPTIDE (ENA-78) GENE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 269, no. 41, 14 October 1994 (1994-10-14), pages 25277 - 25282, XP002049872, ISSN: 0021-9258
  • See references of WO 9735027A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9735027 A1 19970925; AU 5425496 A 19971010; CA 2249995 A1 19970925; EP 0904398 A1 19990331; EP 0904398 A4 20041201

DOCDB simple family (application)

US 9603686 W 19960318; AU 5425496 A 19960318; CA 2249995 A 19960318; EP 96911336 A 19960318