Global Patent Index - EP 0906123 A4

EP 0906123 A4 19990526 - OLIGONUCLEOTIDES TARGETED TO ANGIOTENSINOGEN mRNA

Title (en)

OLIGONUCLEOTIDES TARGETED TO ANGIOTENSINOGEN mRNA

Title (de)

ANGIOTENSINOGEN-mRNA SPEZIFISCHE OLIGONUKLEOTIDE

Title (fr)

OLIGONUCLEOTIDES CIBLES SUR L'ARNm DE L'ANGIOTENSINOGENE

Publication

EP 0906123 A4 19990526 (EN)

Application

EP 97916760 A 19970314

Priority

  • US 9704019 W 19970314
  • US 61686096 A 19960315

Abstract (en)

[origin: WO9733623A1] Oligonucleotides, and compositions thereof, are disclosed which can be administered to human subjects to inhibit the expression of angiotensinogen to thereby control angiotensinogen induced hypertension.

IPC 1-7

A61K 48/00; C07H 21/04

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 9/12 (2006.01); C07H 21/00 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 9/12 (2017.12); C07H 21/00 (2013.01); C12N 15/113 (2013.01); A61K 38/00 (2013.01); C12N 2310/311 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3511 (2013.01); C12N 2310/3535 (2013.01); C12N 2799/021 (2013.01)

Citation (search report)

  • [XY] WO 9530330 A1 19951116 - DZAU VICTOR J [US]
  • [YD] WIELBO, D. ET AL.: "Antisense inhibition of hypertension in the spontaneously hypertensive rat", HYPERTENSION, vol. 25, 1995, pages 314 - 319, XP002098210
  • [X] COOK, J. ET AL.: "Identification and antisense inhibition of a renin-angiotensin system in transgenic cardiomyocytes", AM. J. PHYSIOL. (1995), 268(4, PT. 2), H1471-H1482, XP002098211
  • [A] PHILLIPS, I. ET AL.: "Antisense inhibition of hypertension: a new strategy for renin-angiotensin candidate genes.", KIDNEY INT., vol. 46, 1994, pages 1554 - 1556, XP002098212
  • [A] UHLMANN E ET AL: "ANTISENSE OLIGONUCLEOTIDES: A NEW THERAPEUTIC PRINCIPLE", CHEMICAL REVIEWS, vol. 90, no. 4, 1 June 1990 (1990-06-01), pages 543 - 584, XP000141412
  • [PXD] WIELBO, D. ET AL.: "Inhibition of hypertension by peripheral administration of antisense oligodeoxynucleotides", HYPERTENSION, vol. 28, July 1996 (1996-07-01), pages 147 - 151, XP002098213
  • [PX] PHILLIPS, I.: "Antisense inhibition and adeno-associated viral vector delivery for reducing hypertension", HYPERTENSION, vol. 29, January 1997 (1997-01-01), pages 177 - 187, XP002098214
  • See references of WO 9733623A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9733623 A1 19970918; AU 2529697 A 19971001; CA 2248932 A1 19970918; EP 0906123 A1 19990407; EP 0906123 A4 19990526; JP 2000506866 A 20000606

DOCDB simple family (application)

US 9704019 W 19970314; AU 2529697 A 19970314; CA 2248932 A 19970314; EP 97916760 A 19970314; JP 53285697 A 19970314