EP 0906310 A4 19990901 - OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
Title (en)
OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
Title (de)
OXADIAZOL-BENZOSULFONAMIDE ALS SELEKTIVE BETA-3 ADRENERGISCHE REZEPTOR AGONISTEN ZUR BEHANDLUNG VON DIABETIS UND FETTLEIBIGKEIT
Title (fr)
BENZENESULFONAMIDES D'OXADIAZOLE EN TANT QU'AGONISTES -g(b) 3? SELECTIFS POUR LE TRAITEMENT DU DIABETE ET DE L'OBESITE
Publication
Application
Priority
- GB 9614191 A 19960705
- US 9709536 W 19970603
- US 1929596 P 19960607
Abstract (en)
[origin: WO9746556A1] Oxadiazole substituted benzenesulfonamides are selective beta 3 adrenergic receptor agonists with very little beta 1 and beta 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduce neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/505 (2006.01); A61K 31/517 (2006.01); A61K 31/529 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07D 213/40 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01)
CPC (source: EP)
A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 25/24 (2017.12); A61P 43/00 (2017.12); C07D 213/40 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)
Citation (search report)
- [DX] WO 9529159 A1 19951102 - MERCK & CO INC [US], et al
- See references of WO 9746556A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9746556 A1 19971211; AU 3374897 A 19980105; AU 712057 B2 19991028; CA 2257206 A1 19971211; EP 0906310 A1 19990407; EP 0906310 A4 19990901; JP 2000511903 A 20000912
DOCDB simple family (application)
US 9709536 W 19970603; AU 3374897 A 19970603; CA 2257206 A 19970603; EP 97929769 A 19970603; JP 50078298 A 19970603