Title (en)

THROMBIN INHIBITORS

Title (de)

THROMBININHIBITOREN

Title (fr)

INHIBITEURS DE THROMBINE

Publication

EP 0910583 A1 19990428 (EN)

Application

EP 97925198 A 19970611

Priority

• GB 9701575 W 19970611
• GB 9613718 A 19960629

Abstract (en)

[origin: WO9800443A1] Bifunctional peptide thrombin inhibitors and methods of their manufacture are provided. The inhibitors have an anion-binding exosite associating moiety joined to a catalytic site directed moiety. A spacer peptide and a non-peptide linker moiety enable both the anion-binding exosite associating moiety and the catalytic site directed moiety to bind simultaneously to a thrombin molecule thereby permitting the treatment of thrombosis.

IPC 1-7

C07K 14/815; C07K 5/065; A61K 38/55; A61K 38/58

IPC 8 full level

G01N 33/50 (2006.01); A61K 38/55 (2006.01); A61P 7/02 (2006.01); A61P 43/00 (2006.01); C07K 1/04 (2006.01); C07K 5/06 (2006.01); C07K 7/06 (2006.01); C07K 14/81 (2006.01); C07K 14/815 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); A61P 43/00 (2017.12); C07K 5/06191 (2013.01); C07K 14/815 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9800443A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9800443 A1 19980108; AU 3042697 A 19980121; EP 0910583 A1 19990428; GB 9613718 D0 19960828; JP 2000516203 A 20001205

DOCDB simple family (application)

GB 9701575 W 19970611; AU 3042697 A 19970611; EP 97925198 A 19970611; GB 9613718 A 19960629; JP 50389898 A 19970611