EP 0910640 A2 19990428 - PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS AFFECTING THE ACTIVITY OF G-PROTEIN-COUPLED RECEPTORS BY ALTERING RECEPTOR OLIGOMERIZATION

Title (en)

PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS AFFECTING THE ACTIVITY OF G-PROTEIN-COUPLED RECEPTORS BY ALTERING RECEPTOR OLIGOMERIZATION

Title (de)

PEPTIDE UND PEPTIDOMIMETISCHE MOLEKÜLE DIE, DURCH DIE VERÄNDERUNG DES REZEPTOR OLIGOMERIZATIONSVERFAHREN DIE AKTIVITÄT VON G-PROTEIN-GEKOPPELTE REZEPTOREN BEHINDERN

Title (fr)

PEPTIDES ET COMPOSES PEPTIDOMIMETIQUES AFFECTANT L'ACTIVITE DES RECEPTEURS COUPLES A LA PROTEINE G PAR MODIFICATION DE L'OLIGOMERISATION DES RECEPTEURS

Publication

EP 0910640 A2 19990428 (EN)

Application

EP 97933814 A 19970701

Priority

IB 9700814 W 19970701
US 2103196 P 19960701

Abstract (en)

[origin: WO9800538A2] This invention relates to peptides and peptidomimetic compounds that modulate the function of G-protein-coupled receptors by affecting the ratio of receptor monomer to homo-oligomeric forms. Novel short peptides of a preferred length of up to about 15-20 amino acid residues are modeled on transmembrane domains of G-protein-coupled receptors, whose activities are affected by the formation of oligomers. These novel peptides and peptidomimetic compounds can be used to selectively affect the activity of G-protein-coupling receptors, thereby functioning as potential therapeutic drugs, etc.. A preferred peptide is GIIMGTFTLCWLPFFIVNIV.

IPC 1-7

C12N 15/12; C07K 14/705; C07K 7/08; A61K 38/10; A61K 38/17; G01N 33/68; C07K 14/72; C07K 14/715

IPC 8 full level

C07K 7/08 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/72 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 7/08 (2013.01); C07K 14/705 (2013.01); C07K 14/70571 (2013.01); C07K 14/7158 (2013.01); C07K 14/723 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9800538A2

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9800538 A2 19980108; WO 9800538 A3 19980507; AU 3705097 A 19980121; CA 2205543 A1 19980101; CA 2259132 A1 19980108; EP 0910640 A2 19990428

DOCDB simple family (application)

IB 9700814 W 19970701; AU 3705097 A 19970701; CA 2205543 A 19970702; CA 2259132 A 19970701; EP 97933814 A 19970701