EP 0912187 A2 19990506 - COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS AND REPERFUSION INJURY WITH MAGNESIUM SALTS
Title (en)
COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS AND REPERFUSION INJURY WITH MAGNESIUM SALTS
Title (de)
MITTEL UND VERFAHREN ZUR PRÄVENTION UND BEHANDLUNG DER ATHEROSKLEROSE UND REPERFUSIONSVERLETZUNGEN MITTELS MAGNESIUMSALZEN
Title (fr)
COMPOSITIONS ET PROCEDES S'APPLIQUANT A LA PREVENTION ET AU TRAITEMENT DE L'ATHEROSCLEROSE ET DES LESIONS CONSECUTIVES A DES PERFUSIONS AU MOYEN DE SELS DE MAGNESIUM
Publication
Application
Priority
- US 9700821 W 19970117
- US 58856496 A 19960118
Abstract (en)
[origin: WO9725959A2] The present invention provides compositions and methods for the prevention or treatment of atherosclerosis and reperfusion injury. The method comprises administering to a patient having atherosclerosis an aqueous solution containing magnesium gluconate in an amount sufficient to inhibit oxygen free radical production and lipid peroxidation. In another embodiment the invention provides for the prevention of restenosis in patients undergoing bypass surgery or angioplasty. In a different embodiment, the present invention provides a method for prevention or treatment of ischemic reperfusion injury comprising the step of administering to a patient at risk of reperfusion injury a therapeutically effective amount of magnesium gluconate to inhibit oxygen free radical production. The aqueous solution of the invention comprises magnesium gluconate in an amount sufficient to inhibit oxygen free radical production in cardiac and endothelial tissues.
IPC 1-7
A61K 31/70; A61K 33/10; A61K 47/12; A61K 47/26; A61K 33/06; A61K 31/19
IPC 8 full level
A61K 9/00 (2006.01); A61K 31/191 (2006.01); A61K 33/06 (2006.01); A61K 38/06 (2006.01); A61K 47/26 (2006.01); A61K 47/12 (2006.01)
CPC (source: EP)
A61K 9/0019 (2013.01); A61K 31/191 (2013.01); A61K 33/06 (2013.01); A61K 38/06 (2013.01); A61K 47/26 (2013.01); A61K 47/12 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9725959 A2 19970724; AU 1832197 A 19970811; EP 0912187 A2 19990506; EP 0912187 A4 19990506
DOCDB simple family (application)
US 9700821 W 19970117; AU 1832197 A 19970117; EP 97903853 A 19970117