Global Patent Index - EP 0912193 A4

EP 0912193 A4 20001102 - VACCINE TO PREVENT STREPTOCOCCAL ENDOCARDITIS

Title (en)

VACCINE TO PREVENT STREPTOCOCCAL ENDOCARDITIS

Title (de)

IMPFSTOFF ZUR VERHÜTUNG VON STREPTOKOKKEN ENDOCARDITIS

Title (fr)

VACCIN VISANT A PREVENIR L'ENDOCARDITE STREPTOCOCCIQUE

Publication

EP 0912193 A4 20001102 (EN)

Application

EP 97932373 A 19970620

Priority

  • US 9711329 W 19970620
  • US 2017496 P 19960621

Abstract (en)

[origin: WO9748417A1] FimA proteins from streptococci and enterococci, which are responsible for bacterial adherence to damaged heart tissue, are potent vaccines against a patient developing endocarditis. Recombinantly produced FimA proteins from S. parasanguis provide protection against S. parasanguis derived endocarditis, as well as endocarditis derived from several other streptococci. Conserved DNA regions in viridans streptococci and enterococci suggest that FimA from these strains will be broadly applicable as a vaccine.

IPC 1-7

A61K 39/00; A61K 39/02; A61K 39/38; C07K 1/00; A61K 39/09

IPC 8 full level

C12N 15/00 (2006.01); A61K 39/09 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); C07K 14/315 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP US)

A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); C07K 14/315 (2013.01 - EP); A61K 39/00 (2013.01 - EP US)

Citation (search report)

  • [A] WO 9310238 A1 19930527 - US HEALTH [US]
  • [X] BURNETTE-CURLEY D ET AL: "FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis.", INFECTION AND IMMUNITY, vol. 63, no. 12, December 1995 (1995-12-01), pages 4669 - 4674, XP002145681
  • [X] DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE; 1996, VISCOUNT, HELEN BRAFF: "Pathogenesis and immunology of streptococcal endocarditis (Streptococcus parasanguis)", XP002145683, retrieved from STN Database accession no. 126:168903 & DISSERTATION 120 PP. AVAIL.: UNIV. MICROFILMS INT., ORDER NO. DA9703883 FROM: DISS. ABSTR. INT., B 1997, 57(9), 5475
  • [PX] VISCOUNT H B ET AL: "Immunization with FimA protects against Streptococcus parasanguis endocarditis in rats.", INFECTION AND IMMUNITY, vol. 65, no. 3, March 1997 (1997-03-01), pages 994 - 1002, XP002145682
  • See also references of WO 9748417A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9748417 A1 19971224; AU 3584897 A 19980107; CA 2258011 A1 19971224; EP 0912193 A1 19990506; EP 0912193 A4 20001102; JP 2000514790 A 20001107

DOCDB simple family (application)

US 9711329 W 19970620; AU 3584897 A 19970620; CA 2258011 A 19970620; EP 97932373 A 19970620; JP 50358498 A 19970620