EP 0912511 A1 19990506 - 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION
Title (en)
5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION
Title (de)
5-INDOLYL-2,4-PENTADIENSÄURE-DERIVATE ALS INHIBITOREN DER KNOCHENRESORPTION
Title (fr)
DERIVES D'ACIDE 5-INDOLYLE-2,4-PENTADIENOIQUE POUVANT ETRE UTILISES COMME INHIBITEURS DE LA RESORPTION OSSEUSE
Publication
Application
Priority
- EP 9703710 W 19970707
- GB 9614366 A 19960709
Abstract (en)
[origin: WO9801423A1] A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: R1 represents hydrogen, C1-6 alkyl, halo, azido, C1-6 alkylthio, phnylthio, benzylthio, alkoxyalkyloxy or a group NHR8 wherein R8 represents -CO-R9 or -(CH2)nR11, or R1 represents a group -NR12R13 wherein R12 and R13 each independently represent hydrogen, alkyl or aryl; R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R5 and R6 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R5 and R6 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substitued alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; R7 represents hydrogen, hydroxy, alkanoyl, alkylaminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl; R9 represents R10 or OR10 wherein R10 is C1-6 alkyl, phenyl or benzyl; and R11 represents NR12R13, wherein R12 and R13 are as defined above, or R11 is hydroxy or C1-6 alkoxy; and n represents an integer 1, 2 or 3; a pharmaceutical composition containing such a compound, a process for preparing such a compound and the use of such a compound in medicine.
IPC 1-7
IPC 8 full level
C07D 401/12 (2006.01); A61K 31/404 (2006.01); A61K 31/454 (2006.01); A61P 19/08 (2006.01); C07D 209/18 (2006.01); C07D 401/06 (2006.01)
CPC (source: EP)
A61P 19/08 (2017.12); C07D 209/18 (2013.01); C07D 401/06 (2013.01)
Citation (search report)
See references of WO 9801423A1
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9801423 A1 19980115; EP 0912511 A1 19990506; GB 9614366 D0 19960904; JP 2000514079 A 20001024
DOCDB simple family (application)
EP 9703710 W 19970707; EP 97937473 A 19970707; GB 9614366 A 19960709; JP 50481398 A 19970707