Global Patent Index - EP 0914123 A4

EP 0914123 A4 2000-10-11 - PRODRUGS OF THALIDOMIDE AND METHODS FOR USING SAME AS MODULATORS OF T-CELL FUNCTION

Title (en)

PRODRUGS OF THALIDOMIDE AND METHODS FOR USING SAME AS MODULATORS OF T-CELL FUNCTION

Title (de)

THALIDOMID-PRODRUGS UND VERFAHREN ZUR VERWENDUNG ALS T-ZELL-MODULATOREN

Title (fr)

PRODROGUES DU THALIDOMIDE ET PROCEDES D'UTILISATION DESDITES PRODROGUES COMME MODIFICATEURS DE CELLULE T

Publication

EP 0914123 A4 (EN)

Application

EP 97927902 A

Priority

  • US 9709421 W
  • US 1855896 P

Abstract (en)

[origin: WO9745117A1] The present invention relates to a new, safe and effective form of thalidomide ([N-phthalimido]-glutarimide) and methods of using the same. More specifically, the invention relates to prodrugs of thalidomide and prodrugs of certain analogs of thalidomide, which comprise a thalidomide or analog component having bound thereto the dipeptide sequence X-pro, wherein "X" is one of a wide variety of amino acids and "pro" represents the imino acid proline.

IPC 1-7 (main, further and additional classification)

A61K 31/445

IPC 8 full level (invention and additional information)

A61K 38/05 (2006.01); A61K 47/48 (2006.01); C07K 5/062 (2006.01); C07K 5/068 (2006.01)

CPC (invention and additional information)

C07K 5/06026 (2013.01); A61K 38/05 (2013.01); A61K 47/48338 (2013.01); C07K 5/06086 (2013.01)

Citation (search report)

  • [E] WO 9737988 A1 19971016 - GRUENENTHAL GMBH [DE], et al
  • [X] WO 9218496 A1 19921029 - GRUENENTHAL GMBH [DE]
  • [X] D'AMATO R J ET AL: "Thalidomide is an inhibitor of angiogenesis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1994 APR 26) 91 (9) 4082-5., XP002917515
  • [PX] GUCKIAN, M. (1) ET AL: "Thalidomide analog 3052 reduces NK activity and PHA-induced proliferation in vitro.", IMMUNOLOGY, (1996) VOL. 89, NO. SUPPL. 1, PP. 34. MEETING INFO.: JOINT CONGRESS OF THE BRITISH SOCIETY FOR IMMUNOLOGY AND THE BIOCHEMICAL SOCIETY HARROGATE, ENGLAND, UK DECEMBER 10-13, 1996, XP000917548
  • See also references of WO 9745117A1

Designated contracting state (EPC)

BE CH DE DK FR GB IT LI NL

EPO simple patent family

WO 9745117 A1 19971204; AU 3224997 A 19980105; CA 2256669 A1 19971204; CZ 9803893 A3 19990714; EP 0914123 A1 19990512; EP 0914123 A4 20001011

INPADOC legal status


2001-05-09 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20001114

2000-10-11 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000830

2000-10-11 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): BE CH DE DK FR GB IT LI NL

2000-10-04 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 31/445 A

1999-05-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19981127

1999-05-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE DK FR GB IT LI NL