EP 0914450 A1 19990512 - MITOGEN-ACTIVATED PROTEIN KINASE p38-2 AND METHODS OF USE THEREFOR
Title (en)
MITOGEN-ACTIVATED PROTEIN KINASE p38-2 AND METHODS OF USE THEREFOR
Title (de)
MITOGENAKTIVIERTE PROTEINKINASE P38-2 UND METHODEN ZU DEREN VERWENDUNG
Title (fr)
PROTEINE KINASE p38-2 ACTIVEE PAR MITOGENE ET MODES D'UTILISATION DUDIT PRODUIT
Publication
Application
Priority
- US 9708738 W 19970520
- US 65194096 A 19960520
- US 84008297 A 19970409
Abstract (en)
[origin: WO9744467A1] Compositions and methods are provided for the treatment of conditions associated with mitogen-activated protein kinase cascades. In particular, the mitogen-activated protein kinase p38-2, and polypeptide variants thereof that stimulate phosphorylation and activation of substrates such as ATF2, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit signal transduction via the p38-2 kinase cascade. The polypeptides and agents may be used in a variety of methods, such as in the reduction of pain sensations.
IPC 1-7
C12N 15/54; C12N 9/12; G01N 33/573; C07K 16/40; A61K 38/45; C12Q 1/48; C12N 5/10
IPC 8 full level
C07K 16/40 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/54 (2006.01); C12P 21/08 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/573 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C12N 9/1205 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9744467A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9744467 A1 19971127; AU 3139797 A 19971209; AU 736316 B2 20010726; CA 2255579 A1 19971127; EP 0914450 A1 19990512; JP 2002515744 A 20020528
DOCDB simple family (application)
US 9708738 W 19970520; AU 3139797 A 19970520; CA 2255579 A 19970520; EP 97926689 A 19970520; JP 54275097 A 19970520