Global Patent Index - EP 0914821 A3

EP 0914821 A3 2000-04-26 - Method for diagnosis of atherosclerosis involving measurement of NADPH oxidase activity

Title (en)

Method for diagnosis of atherosclerosis involving measurement of NADPH oxidase activity

Title (de)

Diagnoseverfahren für Atherosklerose mittels Messung der NADPH Oxidase Aktivität

Title (fr)

Méthode de diagnostique de l'athérosclérose impliquant la mesure de l'activité de la NADPH oxidase

Publication

EP 0914821 A3 (EN)

Application

EP 99100764 A

Priority

  • EP 96940912 A
  • US 56276795 A

Abstract (en)

[origin: WO9719679A2] A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothetial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of formula (I). Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.

IPC 1-7 (main, further and additional classification)

C12Q 1/26

IPC 8 full level (invention and additional information)

C12N 9/99 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/235 (2006.01); A61K 45/00 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 31/235 (2013.01); Y10S 514/824 (2013.01)

Citation (search report)

  • [X] O'GORMAN M ET AL: "Rapid whole-blood flow cytometry assay for diagnosis of chronic granulomatous disease", CLIN.DIAGN.LAB.IMMUNOL., vol. 2, no. 2, 1995, pages 227 - 232, XP000872567
  • [X] GAHR M ET AL: "Pathophysiologie, Diagnostik und Therapie von Granulozytenfunktionsstörungen", MONATSSSCHRIFT FÜR KINDERHEILKUNDE, vol. 137, 1989, pages 380 - 389, XP000872484
  • [Y] COLLINS T.: "Biology of disease: endothelial nuclear factor kappa b and the initiation of the atherosclerotic lesion", LABORATORY INVESTIGATION, vol. 1993, no. 68, 1905, pages 499-508, XP000872436
  • [Y] KEANEY J F ET AL: "ATHEROSCLEROSIS, OXIDATIVE STRESS, AND ANTIOXIDANT PROTECTION IN ENDOTHELIUM-DERIVED RELAXING FACTOR ACTION", PROGRESS IN CARDIOVASCULAR DISEASES,US,SAUNDERS, PHILADELPHIA, PA, vol. 38, no. 2, 1 September 1995 (1995-09-01), pages 129 - 154, XP000652570, ISSN: 0033-0620

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9719679 A2 19970605; WO 9719679 A3 19970828; AT 189957 T 20000315; AU 1085997 A 19970619; CA 2238098 A1 19970605; CA 2238098 C 20010130; DE 69606882 D1 20000406; DE 69606882 T2 20000817; EP 0861070 A2 19980902; EP 0861070 B1 20000301; EP 0914821 A2 19990512; EP 0914821 A3 20000426; ES 2144792 T3 20000616; GR 3033067 T3 20000831; JP 2003176224 A 20030624; JP H11507946 A 19990713; US 5763496 A 19980609; US 5902831 A 19990511

INPADOC legal status


2001-01-17 [18W] WITHDRAWN

- Date of withdrawal: 20001115

2000-12-20 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20001026

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A3

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-04-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19990208;LT PAYMENT 19990208;LV PAYMENT 19990208;RO PAYMENT 19990208;SI PAYMENT 19990208

2000-04-12 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 12Q 1/26 A

1999-05-12 [AC] DIVISIONAL APPLICATION (ART. 76) OF:

- Document: EP 861070

1999-05-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

1999-05-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19990208;LT PAYMENT 19990208;LV PAYMENT 19990208;RO PAYMENT 19990208;SI PAYMENT 19990208