Title (en)

STEREOSELECTIVE SYNTHESIS OF ENDOTHELIN RECEPTOR ANTAGONISTS

Title (de)

STEREPSELEKTIVE SYNTHESE VON ENDOTHELINREZEPTOR-ANTAGONISTEN

Title (fr)

SYNTHESE STEREOSELECTIVE D'ANTAGONISTES DE RECEPTEURS D'ENDOTHELINES

Publication

EP 0915699 A4 20080625 (EN)

Application

EP 96939654 A 19961108

Priority

• CA 2236924 A 19961108
• US 9618084 W 19961108
• US 634895 P 19951108

Abstract (en)

[origin: WO9717071A1] The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates.

IPC 1-7

A61K 31/435; A61K 31/70; C07D 221/04

IPC 8 full level

C07D 317/60 (2006.01); C07H 9/04 (2006.01)

CPC (source: EP)

C07D 317/60 (2013.01); C07H 9/04 (2013.01)

Citation (search report)

• [A] WO 9425013 A1 19941110 - SMITHKLINE BEECHAM CORP [US], et al
• [A] WO 9308799 A1 19930513 - SMITHKLINE BEECHAM CORP [US]
• [A] I.C.M.DEA: "Aryl glycosides of oligosaccharides Part II. Bromo-, chloro-, and iodo-phenyl beta-D-glycosides of some disaccharidestables I and II", CARBOHYDR. RES., vol. 12, 1970, pages 297 - 299, XP002452559
• [A] K. TAKEO ET AL.: "Synthesis of methyl alfa- and beta-maltotriosides and aryl beta-maltotriosides", CARBOHYD. RES., vol. 48, 1976, pages 197 - 208, XP002452560
• [A] ELLIOTT J D ET AL: "1,3-DIARYLINDAN-2-CARBOXYLIC ACIDS, POTENT AND SELECTIVE NON- PEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 37, no. 11, 1994, pages 1553 - 1557, XP000652243, ISSN: 0022-2623
• See references of WO 9717071A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

DOCDB simple family (publication)

WO 9717071 A1 19970515; AU 7677496 A 19970529; CA 2236924 A1 19970515; EP 0915699 A1 19990519; EP 0915699 A4 20080625

DOCDB simple family (application)

US 9618084 W 19961108; AU 7677496 A 19961108; CA 2236924 A 19961108; EP 96939654 A 19961108