EP 0915849 A2 19990519 - PROCESS FOR THE PREPARATION OF 3,3-DISUBSTITUTED PIPERIDINES
Title (en)
PROCESS FOR THE PREPARATION OF 3,3-DISUBSTITUTED PIPERIDINES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 3,3-DISUBSTITUIERTEN PIPERIDINEN
Title (fr)
PROCEDE DE PREPARATION DE PIPERIDINES 3,3-BISUBSTITUEES
Publication
Application
Priority
- EP 9704275 W 19970804
- GB 9616417 A 19960805
- GB 9617594 A 19960822
Abstract (en)
[origin: WO9805640A2] A process for preparing a compound of formula (I), wherein R1 represents hydrogen or a protecting group; and R2 represents hydrogen or benzoyl optionally substituted in the phenyl moiety with halogen, methyl or C1-4 alkoxy; which process comprises cyclising a compound of formula (II), wherein R1 is as defined in relation to (I), to provide a cyclic lactam of formula (III), wherein R1 is as defined in relation to (I); reducing the compound of formula (III) so formed to provide a compound of formula (I) wherein R2 represents hydrogen; and thereafter carrying out one or more of the following optional steps: (a) N-acylating the compound of formula (I) wherein R2 represents hydrogen to provide a compound of formula (I) wherein R2 represents benzoyl wherein the phenyl moiety is optionally substituted with halogen, methyl or C1-4 alkoxy; and (b) removing any protecting group.
IPC 1-7
IPC 8 full level
C07B 57/00 (2006.01); C07D 211/22 (2006.01); C07D 211/58 (2006.01); C07D 211/88 (2006.01)
CPC (source: EP)
C07B 57/00 (2013.01); C07D 211/22 (2013.01); C07D 211/58 (2013.01); C07D 211/88 (2013.01); Y02P 20/55 (2015.11)
Citation (search report)
See references of WO 9805640A2
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9805640 A2 19980212; WO 9805640 A3 19980522; EP 0915849 A2 19990519; JP 2000515534 A 20001121
DOCDB simple family (application)
EP 9704275 W 19970804; EP 97937554 A 19970804; JP 50762498 A 19970804