EP 0917493 A1 19990526 - SOLID PHASE ORGANIC SYNTHESIS DEVICE WITH PRESSURE-REGULATED MANIFOLD
Title (en)
SOLID PHASE ORGANIC SYNTHESIS DEVICE WITH PRESSURE-REGULATED MANIFOLD
Title (de)
FESTPHASENSYNTHESEVORRICHTUNG MIT DRUCKREGULIERTEM VERTEILERBLOCK
Title (fr)
DISPOSITIF DE SYNTHESE ORGANIQUE EN PHASE SOLIDE MUNI D'UN COLLECTEUR REGULE PAR PRESSION
Publication
Application
Priority
- US 9714179 W 19970811
- US 69572096 A 19960812
- US 90012097 A 19970725
Abstract (en)
[origin: WO9806490A1] A solid phase organic synthesis device (10) comprising a manifold (12) and an optional heating block (16) mounted to an upper surface of the manifold. The manifold includes an internal cavity and a first array of holes (33) coupled to the internal cavity. The heating block (16) includes a second array of holes (52) vertically aligned with the corresponding holes (33) of the first array. The first and second arrays of holes (33, 52) are adapted to accommodate flow-through reaction vessels (54). Each reaction vessel (54) is secured in one of the holes (33) of the first array and a vertical-aligned one of the holes of the second array (54). The interiors of the reaction vessels (54) are in communication with the internal cavity of the manifold (12). The flow-through reaction vessels (54), which contain solid phase resins for solid phase organic synthesis, are controlled by regulating the pressure within the manifold. The manifold (12) includes a pressure port (24) coupled to both an inert gas source and a pressure control device (25), and a vacuum port (26) coupled to a vacuum control device (31) and a vacuum source. The pressure control device (25) and the vacuum control device (31) are easily operated to create a vacuum and varying degrees of positive pressure within the manifold (12) as required when carrying out an organic synthesis. A second manifold (63) is mounted on the first manifold (12) in the absence of the reaction vessels (54) for supplying inert gas used to concentrate organic synthesis products.
IPC 1-7
IPC 8 full level
B01J 4/00 (2006.01); B01J 19/00 (2006.01); C40B 50/14 (2006.01); C40B 60/14 (2006.01)
CPC (source: EP)
B01J 19/0046 (2013.01); B01J 2219/00286 (2013.01); B01J 2219/00308 (2013.01); B01J 2219/0031 (2013.01); B01J 2219/00416 (2013.01); B01J 2219/00418 (2013.01); B01J 2219/00423 (2013.01); B01J 2219/00454 (2013.01); B01J 2219/00493 (2013.01); B01J 2219/005 (2013.01); B01J 2219/00585 (2013.01); B01J 2219/0059 (2013.01); B01J 2219/00596 (2013.01); C40B 50/14 (2013.01); C40B 60/14 (2013.01)
Citation (search report)
See references of WO 9806490A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9806490 A1 19980219; AU 4062597 A 19980306; EP 0917493 A1 19990526; JP 2002514132 A 20020514
DOCDB simple family (application)
US 9714179 W 19970811; AU 4062597 A 19970811; EP 97938249 A 19970811; JP 50996298 A 19970811