EP 0917567 A1 19990526 - PLASMINOGEN ACTIVATOR CAPABLE OF BEING ACTIVATED BY THROMBIN
Title (en)
PLASMINOGEN ACTIVATOR CAPABLE OF BEING ACTIVATED BY THROMBIN
Title (de)
THROMBINAKTIVIERBARER PLASMINOGENAKTIVATOR
Title (fr)
ACTIVATEUR DU PLASMINOGENE ACTIVABLE PAR THROMBINE
Publication
Application
Priority
- EP 97934509 A 19970721
- EP 9703925 W 19970721
- EP 96112487 A 19960802
Abstract (en)
[origin: WO9805762A1] A plasminogen activator (t-PA) is (a) modified in such a way that it can be split by thrombin and thus turned into its two-chain form; (b) modified in such a way that its zymogenity is at least 1.2 higher than that of t-PA; and (c) its fibrin binding power is so reduced that more than 50 % of the plasminogen activator can enter a blood clot. This plasminogen activator has an improved fibrin-specificity and less side effects.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 8/00 (2006.01); A61K 38/46 (2006.01); A61K 38/49 (2006.01); A61Q 1/00 (2006.01); A61Q 1/02 (2006.01); C12N 1/21 (2006.01); C12N 9/64 (2006.01); C12N 9/72 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
C12N 9/6456 (2013.01 - KR); C12N 9/6459 (2013.01 - EP); C12Y 304/21069 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Citation (search report)
See references of WO 9805762A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9805762 A1 19980212; AU 3769797 A 19980225; BR 9711015 A 19990817; CA 2262751 A1 19980212; CN 1226926 A 19990825; EP 0917567 A1 19990526; JP 2000504941 A 20000425; KR 20000029755 A 20000525; TR 199900193 T2 19990322; TW 450996 B 20010821; ZA 976876 B 19990201
DOCDB simple family (application)
EP 9703925 W 19970721; AU 3769797 A 19970721; BR 9711015 A 19970721; CA 2262751 A 19970721; CN 97196933 A 19970721; EP 97934509 A 19970721; JP 50753098 A 19970721; KR 19997000868 A 19990201; TR 9900193 T 19970721; TW 86110829 A 19970728; ZA 976876 A 19970801