EP 0920411 A1 19990609 - DIAGNOSTIC IMAGING CONTRAST AGENT WITH IMPROVED IN-SERUM-RELAXIVITY
Title (en)
DIAGNOSTIC IMAGING CONTRAST AGENT WITH IMPROVED IN-SERUM-RELAXIVITY
Title (de)
DIAGNOSTISCHES BILDERZEUGUNGIS KONTRASTMITTEL MIT VERBESSERTER IN-SERUM-RELAXATION
Title (fr)
AGENT DE CONTRASTE D'IMAGERIE DIAGNOSTIQUE PRESENTANT UNE RELAXIVITE AMELIOREE DANS LE SERUM
Publication
Application
Priority
- EP 9703997 W 19970724
- IT MI961685 A 19960802
Abstract (en)
[origin: WO9805626A1] Compounds of formula (I), both in the racemic and optically active forms in which R is H, or a linear or branched, saturated or unsaturated C1-C20 alkyl, optionally interrupted by one or more -CH(OH)-, -CONH-, -NHCO-, -CO-, -CH(NH2)-, -SO-, -SO2-, SO2NH- groups and/or one or more N, O, S atoms optionally substituted with one or more -COOH groups and/or amide or ester derivatives thereof, and in which said alkyl chain is interrupted or substituted by at least 2, which are independently the same or different, isolated or fused, cyclic L residues, with the proviso that, when some L residues are fused together, the resulting polycyclic unit comprises no more than 3 cyclic group, and in which L is a carbocyclic or heterocyclic, saturated or unsaturated or aromatic cyclic unit, comprising from 5 to 6 atoms, optionally substituted by one or more X groups, which are independently the same or different, in which X is OH, halogen, NH2, NHZ, N(Z)2, -OZ-, -SZ-, COZ, where the Z groups can independently be a C1-C5 linear or branched alkyl, optionally substituted with one or more -OH, -COOH or alkoxy groups, or said X group is a -COOH group or a derivative thereof, such as an ester or an amido group, or -SOZH group or an amino derivative of the same; R1 is the same as R with the provisos that: R and R1 cannot be at the same time H; when R is different from H, R1 is H; when R1 is different from H, R is H; as well as the complexes of the compounds of fomula (I) with metal ions of atomic number from 20 to 31, 39, from 42 to 44, 49 and from 57 to 83 and the salts thereof with physiologically acceptable organic bases selected from primary, secondary or tertiary amines, or basic amino acids, or with inorganic bases the cations of which are sodium, potassium, magnesium, calcium or the mixtures thereof. Said compounds are useful as contrast agents in Magnetic Resonance Imaging and have improved relaxivitty in human serum.
IPC 1-7
C07C 229/36; C07C 229/22; A61K 49/00; C07D 209/20; C07C 237/06; C07C 237/04; C07C 233/48; C07C 233/51
IPC 8 full level
A61K 49/06 (2006.01); C07C 229/26 (2006.01); C07C 229/36 (2006.01); C07C 229/76 (2006.01); C07C 233/48 (2006.01); C07C 233/51 (2006.01); C07C 237/04 (2006.01); C07C 237/06 (2006.01); C07D 209/20 (2006.01); A61K 49/00 (2006.01); C07D 263/26 (2006.01); C07F 5/00 (2006.01)
CPC (source: EP)
A61K 49/06 (2013.01); C07C 229/26 (2013.01); C07C 229/36 (2013.01); C07C 233/48 (2013.01); C07C 233/51 (2013.01); C07C 237/06 (2013.01); C07D 209/20 (2013.01); C07D 263/26 (2013.01); C07C 2601/14 (2017.05)
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9805626 A1 19980212; AU 4115997 A 19980225; EP 0920411 A1 19990609; IT 1283651 B1 19980423; IT MI961685 A0 19960802; IT MI961685 A1 19980202; JP 2001522348 A 20011113; JP 4070241 B2 20080402; ZA 976889 B 19980511
DOCDB simple family (application)
EP 9703997 W 19970724; AU 4115997 A 19970724; EP 97938855 A 19970724; IT MI961685 A 19960802; JP 50563698 A 19970724; ZA 976889 A 19970801