Global Patent Index - EP 0921809 A4

EP 0921809 A4 20011024 - USE OF PROLACTIN AS A TGF-BETA ANTAGONIST

Title (en)

USE OF PROLACTIN AS A TGF-BETA ANTAGONIST

Title (de)

VERWENDUNG VON PROLACTIN ALS TGF-BETA ANTAGONIST

Title (fr)

UTILISATION DE LA PROLACTINE COMME UN ANTAGONISTE DE TGF-BETA

Publication

EP 0921809 A4 20011024 (EN)

Application

EP 97921467 A 19970430

Priority

  • US 9707310 W 19970430
  • US 1649296 P 19960430

Abstract (en)

[origin: WO9740848A1] This invention is based upon the discovery that prolactin has been found to counter the effect that TGF- beta has on cells. An object of the present invention is to claim a method for treating a patient that may be suffering from a disease or disorder which is associated with the presence of TGF- beta , by administering an effective amount of a pharmaceutically acceptable composition containing prolactin.

IPC 1-7

A61K 38/17; A61K 38/27; A61K 38/22

IPC 8 full level

A61K 31/00 (2006.01); A61K 38/22 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 11/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP)

A61K 38/225 (2013.01); A61P 1/00 (2017.12); A61P 1/16 (2017.12); A61P 11/00 (2017.12); A61P 37/00 (2017.12); A61P 43/00 (2017.12)

Citation (search report)

  • [X] WO 9521625 A1 19950817 - GENZYME CORP [US]
  • [X] ZHU XIAO-HONG ET AL: "Prolactin inhibits the increased cytokine gene expression in Kupffer cells following haemorrhage.", CYTOKINE, vol. 8, no. 2, 1996, pages 134 - 140, XP001010309, ISSN: 1043-4666
  • [X] SANDI CARMEN ET AL: "Mutually antagonistic effects of corticosterone and prolactin on rat lymphocyte proliferation.", NEUROENDOCRINOLOGY, vol. 56, no. 4, 1992, pages 574 - 581, XP001010477, ISSN: 0028-3835
  • [X] DARCY KATHLEEN M ET AL: "Prolactin and epidermal growth factor regulation of the proliferation, morphogenesis, and functional differentiation of normal rat mammary epithelial cells in three dimensional primary culture.", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 163, no. 2, 1995, pages 346 - 364, XP001010464, ISSN: 0021-9541
  • [XP] RICHARDS S M ET AL: "Recombinant human prolactin is an antagonist of TGF-beta activity.", FASEB JOURNAL, vol. 10, no. 6, 30 April 1996 (1996-04-30), Joint Meeting of the American Society for Biochemistry and Molecular Biology, the American Society for Investigative Pathology and the American Association of Immunologists;New Orleans, Louisiana, USA, pages A1483, XP002172888, ISSN: 0892-6638
  • See references of WO 9740848A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9740848 A1 19971106; AU 2749697 A 19971119; CA 2232682 A1 19971106; EP 0921809 A1 19990616; EP 0921809 A4 20011024; JP 2000510112 A 20000808

DOCDB simple family (application)

US 9707310 W 19970430; AU 2749697 A 19970430; CA 2232682 A 19970430; EP 97921467 A 19970430; JP 53920697 A 19970430