Global Patent Index - EP 0922052 A4

EP 0922052 A4 20010801 - RAT OB RECEPTORS AND NUCLEOTIDES ENCODING THEM

Title (en)

RAT OB RECEPTORS AND NUCLEOTIDES ENCODING THEM

Title (de)

RATTEN-SPEZIFISCHE OB-REZEPTOREN UND NUKLEOTIDE, WELCHE FÜR DIESE KODIEREN

Title (fr)

RECEPTEURS DE L'OBESITE DU RAT ET NUCLEOTIDES CODANT CES RECEPTEURS

Publication

EP 0922052 A4 20010801 (EN)

Application

EP 97905980 A 19970218

Priority

  • GB 9608473 A 19960425
  • US 9702397 W 19970218
  • US 9040596 P 19960222
  • US 1396996 P 19960322

Abstract (en)

[origin: WO9731015A1] The rat ob receptor gene has been isolated and cloned. Two different alleles have been identified: the wild-type, and the fa-allele which differs from the wild-type by only one base pair. The base pair change, however, introduces an MspI restriction site into the DNA sequence, and also results in an amino acid change. Also part of the invention are the novel receptors, vectors containing the nucleic acid encoding the receptors, host cells transformed with this gene, and assays which use the gene or protein and identify new ligands.

IPC 1-7

C07K 5/00; C07H 21/02; C07H 21/04; C12N 15/70; C12N 5/10; C12N 1/19; C12N 1/21; C12N 15/63; C12P 19/34; C12P 21/00; C07K 14/72

IPC 8 full level

C07K 14/705 (2006.01); C07K 14/72 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); C12R 1/19 (2006.01)

CPC (source: EP)

C07K 14/72 (2013.01)

Citation (search report)

  • [Y] CHUA S C ET AL: "PHENOTYPES OF MOUSE DIABETES AND RAT FATTY DUE TO MUTATIONS IN THE OB (LEPTIN) RECEPTOR", SCIENCE,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,,US, vol. 271, 16 February 1996 (1996-02-16), pages 994 - 996, XP000941868, ISSN: 0036-8075
  • [Y] STEPHENS ET AL.: "The role of neuropeptide Y in the antiobesity action of the obese gene product", NATURE, vol. 377, 12 October 1995 (1995-10-12), pages 530 - 532, XP000999194
  • [PX] IIDA M ET AL: "SUBSTITUTION AT CODON 269 (GLUTANINE PROLINE) OF THE LEPTIN RECEPTOR (OB-R) CDNA IS THE ONLY MUTATION FOUND IN THE ZUCKER FATTY (FA/FA) RAT", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 224, no. 2, 16 July 1996 (1996-07-16), pages 597 - 604, XP002029745, ISSN: 0006-291X
  • [PX] PHILLIPS ET AL.: "Leptin receptor missense mutation in the fatty Zucker rat", NATURE GENETICS, 13 May 1996 (1996-05-13), pages 18-19, XP000611494
  • See references of WO 9731015A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9731015 A1 19970828; CA 2246226 A1 19970828; EP 0922052 A1 19990616; EP 0922052 A4 20010801; JP 2002515739 A 20020528

DOCDB simple family (application)

US 9702397 W 19970218; CA 2246226 A 19970218; EP 97905980 A 19970218; JP 53025497 A 19970218