EP 0923596 A2 19990623 - LIPOPHILIC OLIGONUCLEOTIDE ANALOGS
Title (en)
LIPOPHILIC OLIGONUCLEOTIDE ANALOGS
Title (de)
LIPOPHILE OLIGNUCLEOTIDANALOGA
Title (fr)
ANALOGUES LIPOPHILES D'OLIGONUCLEOTIDES
Publication
Application
Priority
- CA 2261704 A 19960731
- US 9612530 W 19960731
Abstract (en)
[origin: WO9804575A2] The invention discloses lipophilic oligonucleotide analogs that are capable of efficient passive diffusion across cell membranes. These oligonucleotides contain at least two nucleotide residues and have an octanol:water partition coefficient of about -0.3 to + 2.5 and a solubility in water of at least 0.001 mu g/mL. Invention embodiments which include lipophilic oligonucleotide analogs having either at least 60 % of the internucleotide linkages are lipophilic, or at least 60 % of the bases contain lipophilic substitutions, or at least 60 % of the sugars contain lipophilic substitutions, or a combination of these sums to 60 %. These oligonucleotides may be conjugated to a label and used to visualize cells or subcellular compartments.
IPC 1-7
IPC 8 full level
C07H 21/00 (2006.01)
CPC (source: EP)
C07H 21/00 (2013.01)
Citation (search report)
See references of WO 9804575A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9804575 A2 19980205; WO 9804575 A3 19980319; CA 2261704 A1 19980205; EP 0923596 A2 19990623
DOCDB simple family (application)
US 9612530 W 19960731; CA 2261704 A 19960731; EP 96926831 A 19960731