EP 0925280 A1 19990630 - NOVEL N-PROTECTED ALPHA-AMINO SULPHINIC ACID SALTS, METHOD FOR PREPARING SAME, AND SULPHONOPEPTIDES DERIVED THEREFROM
Title (en)
NOVEL N-PROTECTED ALPHA-AMINO SULPHINIC ACID SALTS, METHOD FOR PREPARING SAME, AND SULPHONOPEPTIDES DERIVED THEREFROM
Title (de)
N-GESCHÜTZTE ALPHA-AMINOSULFINSÄURESALZE, VERFAHREN ZU IHRER HERSTELLUNG SOWIE DIE DARAUS ABGELEITETEN SULFONOPEPTIDEN
Title (fr)
NOUVEAUX SELS N PROTEGES D'ACIDE ALPHA-AMINO SULFINIQUE, LEUR PROCEDE D'OBTENTION, ET LES SULFONOPEPTIDES QUI EN DERIVENT
Publication
Application
Priority
- FR 9701185 W 19970703
- FR 9609845 A 19960731
Abstract (en)
[origin: WO9804522A1] A method for preparing N-protected alpha -amino sulphinic acid salts having formula Y - NH - CR'R - SO2<->, M<+> is disclosed. An intermediate compound Y - NH - CR'R - R1 is reacted with a sulphinic hydroxyacid salt in a strongly basic medium. The resulting salts, wherein Y is an acyl grouping other than R" SO2, where R" is methyl or PCH3C6H4, R is a halogenated carbon group, alkyl or aryl, R' is hydrogen, a halogenated carbon group, alkyl or aryl, and M<+> is a cation, are also disclosed. Furthermore, stable sulphonopeptides derived from said salts by electrophilic amination are disclosed.
IPC 1-7
IPC 8 full level
C07C 311/32 (2006.01); C07C 311/47 (2006.01); C07C 313/04 (2006.01); C07C 313/06 (2006.01)
CPC (source: EP)
C07C 311/32 (2013.01); C07C 311/47 (2013.01); C07C 313/04 (2013.01); C07C 313/06 (2013.01)
Citation (search report)
See references of WO 9804522A1
Designated contracting state (EPC)
AT BE CH DE ES FR GB IE IT LI NL
DOCDB simple family (publication)
WO 9804522 A1 19980205; EP 0925280 A1 19990630; FR 2751973 A1 19980206; FR 2751973 B1 19980911
DOCDB simple family (application)
FR 9701185 W 19970703; EP 97931852 A 19970703; FR 9609845 A 19960731