EP 0927033 A4 19990707 -
Publication
Application
Priority
- US 9711452 W 19970701
- US 67448196 A 19960702
- US 88321997 A 19970626
Abstract (en)
[origin: WO9800127A1] This invention relates to the novel retinoyloxy(substituted)alkylene butyrate compounds and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment by comprising administering those compounds, pharmaceutically-acceptable salts or prodrugs thereof to a patient. The compounds of the invention are also useful in methods of inhibiting histone deacetylase, ameliorating wrinkles, treating or ameliorating dermatological disorders, inducing wound healing, treating cutaneous ulcers and treating gastrointestinal disorders.
IPC 1-7
IPC 8 full level
A61K 31/215 (2006.01); A61K 31/22 (2006.01); A61K 31/225 (2006.01); A61K 31/232 (2006.01); A61K 31/44 (2006.01); A61P 1/00 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 17/10 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 403/10 (2006.01); C07C 403/20 (2006.01); C07D 213/30 (2006.01); C07D 213/55 (2006.01); C07D 239/26 (2006.01); C07D 307/42 (2006.01); C07D 333/38 (2006.01); C11C 3/00 (2006.01)
IPC 8 main group level
C07C (2006.01)
CPC (source: EP)
A61K 31/232 (2013.01); A61K 35/74 (2013.01); A61K 38/21 (2013.01); A61K 45/06 (2013.01); A61P 1/00 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 17/10 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07C 403/20 (2013.01); C07D 213/30 (2013.01); C07B 2200/09 (2013.01); C07C 2601/16 (2017.04)
Citation (search report)
- [X] WO 8900157 A1 19890112 - MOLECULAR DESIGN INT [US]
- [DX] WO 9006751 A1 19900628 - MOLECULAR DESIGN INT [US]
- [DX] US 4677120 A 19870630 - PARISH HARLIE A [US], et al
- [X] EP 0449099 A2 19911002 - HOFFMANN LA ROCHE [CH]
- [E] US 5710176 A 19980120 - REPHAELI ADA [US], et al
- See references of WO 9800127A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9800127 A1 19980108; AU 3588097 A 19980121; CA 2258593 A1 19980108; EP 0927033 A1 19990707; EP 0927033 A4 19990707; IL 127739 A0 19991028; JP 2002514161 A 20020514
DOCDB simple family (application)
US 9711452 W 19970701; AU 3588097 A 19970701; CA 2258593 A 19970701; EP 97932417 A 19970701; IL 12773997 A 19970701; JP 50440398 A 19970701