Title (en)

P1, P4-DITHIO-P2,P3-MONOCHLOROMETHYLENE 5', 5'''-DIADENOSINE P1, P4-TETRAPHOSPHATE AS ANTITHROMBOTIC AGENT

Title (de)

P1, P4-DITHIO-P2,P3-MONOCHLOROMETHYLEN 5',5'''-DIADENOSIN-P1,P4-TETRAPHOSPHAT VERWENDET ALS ANTI-THROMBOSE MITTEL

Title (fr)

P1,P4-DITHIO-P2,P3-MONOCHLOROMETHYLENE-5',5'''-DIADENOSINE-P1,P4-TETRAPHOSPHATE UTILISE COMME AGENT ANTI-THROMBOSE

Publication

EP 0927038 A4 20000726 (EN)

Application

EP 97922603 A 19970501

Priority

• US 9707377 W 19970501
• US 64302996 A 19960502

Abstract (en)

[origin: US5681823A] A novel composition, P1, P4-dithio-P2, P3-monochloromethylene 5', 5'''-diadenosine P1, P4-tetraphosphate, is disclosed. The composition is useful as a therapeutic agent for prevention of thrombosis and for modulating a thrombolytic effect in a mammal.

IPC 1-7

A61K 31/70; C07H 21/00

IPC 8 full level

C07H 21/02 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7084 (2006.01); A61K 38/49 (2006.01); A61P 7/00 (2006.01); A61P 7/02 (2006.01); C07H 21/00 (2006.01)

CPC (source: EP US)

A61K 31/7048 (2013.01 - EP US); A61P 7/00 (2017.12 - EP); A61P 7/02 (2017.12 - EP)

Citation (search report)

• [A] B.K.KIM ET AL.: "Antithrombotic Effect of B,B'-Monochloromethylene Diadenosine 5',5'''-P1,P4-tetraphosphate.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 89, no. 22, 15 November 1992 (1992-11-15), NATIONAL ACADEMY OF SCIENCE. WASHINGTON., US, pages 11056 - 11058, XP002138187, ISSN: 0027-8424
• [A] P.C.ZAMECNIK ET AL.: "Analogues of Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as Potential Antiplatelet Aggregation Agents.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 89, no. 6, 15 March 1992 (1992-03-15), NATIONAL ACADEMY OF SCIENCE. WASHINGTON., US, pages 2370 - 2373, XP002138188, ISSN: 0027-8424
• [PX] S.W.CHAN ET AL.: "P1,P4-dithio-P2,P3-monochloromethylene 5',5'''-diadenosine P1,P4-tetraphosphate : A novel antiplatelet agent.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, no. 8, April 1997 (1997-04-01), NATIONAL ACADEMY OF SCIENCE. WASHINGTON., US, pages 4034 - 4039, XP002080574, ISSN: 0027-8424
• See references of WO 9740840A1

Designated contracting state (EPC)

CH DE FR GB LI

DOCDB simple family (publication)

US 5681823 A 19971028; AU 2823097 A 19971119; CA 2252862 A1 19971106; CN 1112930 C 20030702; CN 1220606 A 19990623; DE 69711649 D1 20020508; DE 69711649 T2 20020808; EP 0927038 A1 19990707; EP 0927038 A4 20000726; EP 0927038 B1 20020403; JP 2000509397 A 20000725; JP 4212114 B2 20090121; WO 9740840 A1 19971106

DOCDB simple family (application)

US 64302996 A 19960502; AU 2823097 A 19970501; CA 2252862 A 19970501; CN 97195060 A 19970501; DE 69711649 T 19970501; EP 97922603 A 19970501; JP 53923597 A 19970501; US 9707377 W 19970501