EP 0928202 A4 20010905 - NON-INVASIVE ADMINISTRATION OF ADENO-ASSOCIATED VIRAL VECTORS

Title (en)

NON-INVASIVE ADMINISTRATION OF ADENO-ASSOCIATED VIRAL VECTORS

Title (de)

NICHT-INVASIVE VERABREICHUNG VON ADENO-ASSOZIIERTEN VIRALEN VEKTOREN

Title (fr)

ADMINISTRATION NON INVASIVE DE VECTEUR VIRAUX AAV

Publication

EP 0928202 A4 20010905 (EN)

Application

EP 97909861 A 19970925

Priority

US 9716929 W 19970925
US 2663896 P 19960925

Abstract (en)

[origin: WO9813070A1] The present invention provides new methods of administering recombinant AAV vectors for effective, long-term expression of a gene of interest in animals, including humans. Provided herein are methods of subcutaneously injecting recombinant AAV vectors containing a gene of interest encoding any diffusible polypeptide, ribozyme, nucleic acid, or antisense oligonucleotide for gene therapy. The methods of this invention provide significant advantages, including the ability to deliver any diffusible polypeptide or nucleic acid of a defined size via subcutaneous injection and obtain high-level, long-term expression in regions approximate or distant from the site of subcutaneous injection.

IPC 1-7

A61K 48/00; A61K 9/08; C12N 15/86

IPC 8 full level

A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 38/18 (2006.01); A61K 38/21 (2006.01); A61K 38/22 (2006.01); A61K 38/43 (2006.01); A61K 38/48 (2006.01); A61K 48/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/86 (2006.01); C12N 15/864 (2006.01); C12P 21/02 (2006.01)

CPC (source: EP KR)

A61K 38/1816 (2013.01 - EP); A61K 38/212 (2013.01 - EP); A61K 38/4846 (2013.01 - EP); A61K 48/00 (2013.01 - EP); C12N 15/86 (2013.01 - EP KR); C12N 2750/14143 (2013.01 - EP)

Citation (search report)

[X] WO 9520671 A1 19950803 - RHONE POULENC RORER SA [FR], et al
[X] WO 9527494 A1 19951019 - SLOAN KETTERING INST CANCER [US], et al
See references of WO 9813070A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9813070 A1 19980402; AU 4736797 A 19980417; AU 743335 B2 20020124; CA 2266619 A1 19980402; EP 0928202 A1 19990714; EP 0928202 A4 20010905; JP 2001501819 A 20010213; KR 20000048623 A 20000725

DOCDB simple family (application)

US 9716929 W 19970925; AU 4736797 A 19970925; CA 2266619 A 19970925; EP 97909861 A 19970925; JP 51580598 A 19970925; KR 19997002564 A 19990325