Global patent index - EP 0929218 A4

EP 0929218 A4 2001-05-16 - P2Y RECEPTOR ANTAGONISTS

Title (en)

P2Y RECEPTOR ANTAGONISTS

Title (de)

R2Y REZEPTOR ANTAGONISTEN

Title (fr)

ANTAGONISTES DES RECEPTEURS P2Y

Publication

EP 0929218 A4 (EN)

Application

EP 97952172 A

Priority

  • US 9719922 W
  • US 2985596 P

Abstract (en)

[origin: WO9818430A2] Novel P2Y receptor antagonists derived from ATP and UTP are described. P2Y receptor antagonists with competitive antagonist activity at the P2Y receptor are described in particular, as are P2Y receptor antagonists that bind selectively to the P2Y1 receptor. Also described herein are methods of detecting a P2Y receptor in a biological sample.

IPC 1-7 (main, further and additional classification)

A01N 43/04; A61K 31/70; C07H 1/00; C07H 19/00; C07H 19/04; C07H 19/10; C07H 19/20

IPC 8 full level (invention and additional information)

G01N 33/566 (2006.01); A61K 31/7072 (2006.01); A61K 31/7076 (2006.01); A61P 5/00 (2006.01); A61P 9/08 (2006.01); A61P 13/10 (2006.01); A61P 43/00 (2006.01); C07H 19/10 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01)

CPC (invention and additional information)

C07H 19/16 (2013.01); C07H 19/20 (2013.01)

Citation (search report)

  • [X] WO 9629345 A1 19960926 - UNIV PENNSYLVANIA [US], et al
  • [X] DE 2331223 A1 19740117 - KOHJIN CO
  • [X] GB 1433507 A 19760428 - TAKEDA CHEMICAL INDUSTRIES LTD
  • [X] US 3846402 A 19741105 - ECKSTEIN F, et al
  • [X] US 4266048 A 19810505 - HORWITZ JEROME P, et al
  • [X] US 4828979 A 19890509 - KLEVAN LEONARD [US], et al
  • [X] US 4719295 A 19880112 - COOK PHILLIP D [US], et al
  • [X] WO 9510287 A1 19950420 - WISCONSIN ALUMNI RES FOUND [US]
  • [X] WO 9418216 A1 19940818 - ASTRA PHARMA PROD [GB], et al
  • [X] WO 9217488 A1 19921015 - FISONS PLC [GB]
  • [X] FISCHER, B. ET AL.: "Identification of potent, selective P2Y-purinoreceptor antagonists: relationship or 2-thioether derivatives of adenosine 5'-triphosphate", J. MED. CHEM., vol. 36, 1993, pages 3937 - 46, XP002155543
  • [X] VAN RHEE, A.M. ET AL.: "Novel competitive antagonists for P2 purinoreceptors", EUR. J. PHARMACOL. MOL. PHARMACOL. SECT., vol. 268, 1994, pages 1 - 7, XP000944973
  • [X] BRENNAN, C.A. AND GUMPORT, R. I.: "T4 RNA ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of thermal stabilities", NUCLEIC ACIDS RES., vol. 13, 1985, pages 8665 - 84, XP000944971
  • [PX] BOYER, J.L. ET AL.: "Identification of competitive antagonists of the P2Y1 receptor", MOL. PHARMACOL., vol. 50, 1996, pages 1323 - 9, XP000944991
  • See also references of WO 9818430A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9818430 A2 19980507; WO 9818430 A3 19980618; AU 5584698 A 19980522; CA 2241687 A1 19980507; EP 0929218 A2 19990721; EP 0929218 A4 20010516; JP 2001504097 A 20010327

INPADOC legal status

2001-11-14 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010502

2001-05-16 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010330

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-02-07 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7A 01N 43/04 A, 7C 07H 1/00 B, 7C 07H 19/00 B, 7C 07H 19/04 B, 7C 07H 19/20 B, 7C 07H 19/10 B, 7A 61K 31/70 B

1999-07-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19981019

1999-07-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE