EP 0929537 A1 19990721 - TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS
Title (en)
TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS
Title (de)
TROPONYL PIPERAZINE ALS SELEKTIVE DOPAMIN D4 REZEPTOR LIGANDEN
Title (fr)
PIPERAZINES DE TROPONYLE EN TANT QUE LIGANDS SELECTIFS DU RECEPTEUR D4 DE DOPAMINE
Publication
Application
Priority
- US 9713264 W 19970730
- US 70137096 A 19960822
Abstract (en)
[origin: WO9807711A1] Described herein are compounds of general formula (I), a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, wherein: R1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C1-4alkyl, C1-4alkoxy, nitro, trifluoromethyl, trifluoromethoxy or cyano; R2 is C4-9alkyl; phenyl or phenyl substituted with one or two groups selected independently from OH, cyano, halo, C1-4alkoxy, C1-4alkyl, trifluoromethyl, trifluoromethoxy, nitro or phenyl; naphthyl; phenyl fused to a 5 or 6-membered heterocycle; the coumarin moiety (a), wherein R3 and R4 are selected independently from H, C1-4alkyl and C1-4alkoxy; or 1,2-methylenedioxy phenyl; with the proviso that R2 is not phenyl or 3,4-dimethoxyphenyl when R1 is H. Also described is their use as pharmaceuticals to treat indications in which the dopamine D4 receptor is implicated, such as schizophrenia and anxiety.
IPC 1-7
IPC 8 full level
C07D 295/10 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 43/00 (2006.01); C07D 243/38 (2006.01); C07D 295/112 (2006.01); C07D 295/155 (2006.01); C07D 317/58 (2006.01); C07D 317/66 (2006.01); C07D 409/12 (2006.01)
CPC (source: EP KR)
A61K 31/495 (2013.01 - EP); A61K 31/496 (2013.01 - EP); A61P 25/00 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 243/38 (2013.01 - EP); C07D 295/10 (2013.01 - KR); C07D 295/112 (2013.01 - EP); C07D 295/155 (2013.01 - EP); C07D 317/66 (2013.01 - EP); C07D 409/12 (2013.01 - EP)
Citation (search report)
See references of WO 9807711A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9807711 A1 19980226; AR 009274 A1 20000412; AU 3817197 A 19980306; BR 9711965 A 19990824; CA 2259515 A1 19980226; CN 1227550 A 19990901; EP 0929537 A1 19990721; HU P9903913 A2 20000928; HU P9903913 A3 20001128; IL 128629 A0 20000131; JP 2000516629 A 20001212; KR 20000068255 A 20001125; NO 990796 D0 19990219; NO 990796 L 19990219; NZ 333519 A 19991028; ZA 977445 B 19980223
DOCDB simple family (application)
US 9713264 W 19970730; AR P970103771 A 19970820; AU 3817197 A 19970730; BR 9711965 A 19970730; CA 2259515 A 19970730; CN 97197238 A 19970730; EP 97935166 A 19970730; HU P9903913 A 19970730; IL 12862997 A 19970730; JP 51075498 A 19970730; KR 19997001390 A 19990220; NO 990796 A 19990219; NZ 33351997 A 19970730; ZA 977445 A 19970819