EP 0931091 A1 19990728 - INHIBITORS OF PLA 2
Title (en)
INHIBITORS OF PLA 2
Title (de)
PLA 2 INHIBITOREN
Title (fr)
INHIBITEURS DES PLA 2
Publication
Application
Priority
- AU 9700648 W 19970929
- AU PO266096 A 19960927
- AU PO266196 A 19960927
Abstract (en)
[origin: WO9813376A1] The present invention relates to a three-dimensional structure which inhibits the activity of PLA2. In one particular aspect the structure has a conformation and polarity such that it binds to (i) at least one amino acid in the N-terminal helix region of PLA2; and/or (ii) at least one amino acid in the region spanning residues (70-77) of PLA2. In another aspect the structure is a peptide comprising D-amino acids which has a sequence corresponding to the reverse sequence of a region between residues (69 and 75) of PLA2.
IPC 1-7
IPC 8 full level
C12N 9/99 (2006.01); A61K 38/55 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); C07K 7/04 (2006.01); C07K 7/06 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 19/02 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); C07K 7/06 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9813376 A1 19980402; CA 2266746 A1 19980402; EP 0931091 A1 19990728; EP 0931091 A4 20000614; JP 2001501199 A 20010130
DOCDB simple family (application)
AU 9700648 W 19970929; CA 2266746 A 19970929; EP 97941734 A 19970929; JP 51507698 A 19970929