EP 0931091 A4 20000614 - INHIBITORS OF PLA 2
Title (en)
INHIBITORS OF PLA 2
Title (de)
PLA 2 INHIBITOREN
Title (fr)
INHIBITEURS DES PLA 2
Publication
Application
Priority
- AU 9700648 W 19970929
- AU PO266096 A 19960927
- AU PO266196 A 19960927
Abstract (en)
[origin: WO9813376A1] The present invention relates to a three-dimensional structure which inhibits the activity of PLA2. In one particular aspect the structure has a conformation and polarity such that it binds to (i) at least one amino acid in the N-terminal helix region of PLA2; and/or (ii) at least one amino acid in the region spanning residues (70-77) of PLA2. In another aspect the structure is a peptide comprising D-amino acids which has a sequence corresponding to the reverse sequence of a region between residues (69 and 75) of PLA2.
IPC 1-7
IPC 8 full level
A61K 38/55 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); C07K 7/04 (2006.01); C07K 7/06 (2006.01); C12N 9/99 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 19/02 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); C07K 7/06 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [A] WO 9301215 A1 19930121 - GARVAN INST MED RES [AU]
- [PX] A TSENG ET AL.: "Native peptide inhibition", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 271, no. 39, 27 September 1996 (1996-09-27), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 23992 - 23998, XP002135015, ISSN: 0021-9258
- See references of WO 9813376A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9813376 A1 19980402; CA 2266746 A1 19980402; EP 0931091 A1 19990728; EP 0931091 A4 20000614; JP 2001501199 A 20010130
DOCDB simple family (application)
AU 9700648 W 19970929; CA 2266746 A 19970929; EP 97941734 A 19970929; JP 51507698 A 19970929