EP 0932684 A2 19990804 - 3' GENOMIC PROMOTER REGION AND POLYMERASE GENE MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES OF THE ORDER DESIGNATED MONONEGAVIRALES
Title (en)
3' GENOMIC PROMOTER REGION AND POLYMERASE GENE MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES OF THE ORDER DESIGNATED MONONEGAVIRALES
Title (de)
MUTATIONEN IN DER GENOMISCHEN 3'PROMOTERREGION UND IM POLYMERASEGEN, DIE FÜR DIE ATTENUIERUNG VON VIREN DER ORDNUNG MONONEGAVIRALES VERANTWORTLICH SIND
Title (fr)
REGION PROMOTRICE 3' DU GENOME ET MUTATIONS DU GENE POLYMERASE RESPONSABLES DE L'ATTENUATION DANS DES VIRUS DE L'ORDRE APPELE MONONEGAVIRALES
Publication
Application
Priority
- US 9716718 W 19970919
- US 2682396 P 19960927
Abstract (en)
[origin: WO9813501A2] Isolated, recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA viruses of the Order Mononegavirales having at least one attenuating mutation in the 3' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against a nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales.
IPC 1-7
C12N 15/45; C12N 15/47; C12N 15/40; C07K 14/12; C07K 14/115; C07K 14/135; C07K 14/145; C12N 7/04; A61K 39/165; A61K 39/155
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61K 39/155 (2006.01); A61K 39/165 (2006.01); C07K 14/08 (2006.01); C07K 14/115 (2006.01); C07K 14/12 (2006.01); C07K 14/135 (2006.01); C07K 14/145 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/45 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP KR)
C07K 14/005 (2013.01 - EP); C12N 7/00 (2013.01 - KR); C12N 15/11 (2013.01 - KR); A61K 39/00 (2013.01 - EP KR); C12N 2760/18422 (2013.01 - EP); C12N 2760/18522 (2013.01 - EP); C12N 2760/18622 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9813501 A2 19980402; WO 9813501 A3 19980813; AU 4427897 A 19980417; BR 9712138 A 20000118; CA 2265554 A1 19980402; CN 1232504 A 19991020; EP 0932684 A2 19990804; JP 2000517194 A 20001226; KR 20000048628 A 20000725
DOCDB simple family (application)
US 9716718 W 19970919; AU 4427897 A 19970919; BR 9712138 A 19970919; CA 2265554 A 19970919; CN 97198321 A 19970919; EP 97942613 A 19970919; JP 51574998 A 19970919; KR 19997002569 A 19990325