EP 0935600 A1 19990818 - METHOD OR PRODUCING NAPHTHYRIDINE COMPOUNDS AND NOVEL INTERMEDIATE PRODUCTS
Title (en)
METHOD OR PRODUCING NAPHTHYRIDINE COMPOUNDS AND NOVEL INTERMEDIATE PRODUCTS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON NAPHTHYRIDINVERBINDUNGEN UND NEUE ZWISCHENPRODUKTE
Title (fr)
PROCEDE DE FABRICATION DE COMPOSES DE NAPHTYRIDINE ET NOUVEAUX PRODUITS INTERMEDIAIRES
Publication
Application
Priority
- DE 19643826 A 19961030
- DE 19648214 A 19961121
- EP 9705743 W 19971017
Abstract (en)
[origin: WO9818795A1] An advantageous method of producing naphthyridine compounds of formulae (Ia) to (1c) wherein R means hydrogen or C1-C4 alkyl, Ar means possibly substituted phenyl, Hal means independently fluorine, chlorine or bromine, and n stands for 1, 2 or 3, whereby a halogenated nicotinic, isonicotinic or picolinic acid is made to react with an amino acrylic acid ester to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which is made to react with an optionally substituted aniline to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which contains an amino group corresponding to the optionally substituted aniline. The second halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate is cyclized by adding an acid scavenger to a compound of formulae (Ia) to (Ic) with R = C1-C4 alkyl and, in the case of production of a compound of formulae (Ia) to (Ic) with R = H, the compound of the formulae (Ia) to (Ic) with R = C1-C4 alkyl is saponified.
IPC 1-7
IPC 8 full level
C07D 211/84 (2006.01); C07D 213/26 (2006.01); C07D 213/61 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR)
C07D 211/84 (2013.01 - EP); C07D 213/26 (2013.01 - EP); C07D 213/61 (2013.01 - EP); C07D 471/04 (2013.01 - EP KR)
Citation (search report)
See references of WO 9818795A1
Designated contracting state (EPC)
AT BE CH DE ES FI FR GB IE IT LI NL PT
DOCDB simple family (publication)
WO 9818795 A1 19980507; AU 5050898 A 19980522; CA 2269984 A1 19980507; CN 1235605 A 19991117; CZ 154999 A3 19990811; EP 0935600 A1 19990818; IL 129597 A0 20000229; JP 2001502715 A 20010227; KR 20000052892 A 20000825; PL 332941 A1 19991025
DOCDB simple family (application)
EP 9705743 W 19971017; AU 5050898 A 19971017; CA 2269984 A 19971017; CN 97199280 A 19971017; CZ 154999 A 19971017; EP 97913157 A 19971017; IL 12959797 A 19971017; JP 51998998 A 19971017; KR 19997003756 A 19990429; PL 33294197 A 19971017