EP 0937095 A1 19990825 - TARGETED CYTOLYSIS OF CANCER CELLS
Title (en)
TARGETED CYTOLYSIS OF CANCER CELLS
Title (de)
GEZIELTE ZYTOLYSE VON KREBSZELLEN
Title (fr)
CYTOLYSE CIBLEE DE CELLULES CANCEREUSES
Publication
Application
Priority
- US 2902996 P 19961025
- US 9718707 W 19971024
Abstract (en)
[origin: WO9818809A1] Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to TAG-72 in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signalling pathway. Binding of TAG-72 to the extracellular domain results in transduction of a signal and activation of a signalling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types. A suitable extracellular domain is a single-chain antibody.
IPC 1-7
C07H 19/00; C07H 21/00; C07H 21/04; C07K 1/00; C07K 14/00; C12N 7/01; C12N 15/00; C12N 15/10; C12N 15/12; C12N 15/63; C12N 15/70
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/28 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C07K 16/42 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 7/01 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/7051 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C07K 16/30 (2013.01); A61K 38/00 (2013.01); C07K 2317/732 (2013.01); C07K 2319/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9818809 A1 19980507; AU 4905897 A 19980522; AU 744160 B2 20020214; CA 2269738 A1 19980507; EP 0937095 A1 19990825; EP 0937095 A4 19991222; JP 2002512502 A 20020423
DOCDB simple family (application)
US 9718707 W 19971024; AU 4905897 A 19971024; CA 2269738 A 19971024; EP 97911757 A 19971024; JP 52053098 A 19971024