EP 0938318 B1 20010502 - TABLET WITH CONTROLLED RELEASE OF ALFUZOSINE CHLORYDRATE
Title (en)
TABLET WITH CONTROLLED RELEASE OF ALFUZOSINE CHLORYDRATE
Title (de)
TABLETTE MIT GESTEUERTER FREISETZUNG VON ALFUZOSINHYDROCHLORID
Title (fr)
COMPRIME A LIBERATION CONTROLEE DE CHLORHYDRATE D'ALFUZOSINE
Publication
Application
Priority
- FR 9701515 W 19970822
- FR 9610551 A 19960829
- FR 9704386 A 19970410
Abstract (en)
[origin: WO9808515A1] The invention concerns a pharmaceutical tablet for oral administration, for the controlled release of alfuzosine chlorhydrate at the proximal segments of the gastrointestinal tract, characterised in that it consists of: a) a first layer (1) capable of swelling noticeably and rapidly in contact with aqueous biological liquids, said layer being produced by a mixture or a granule containing hydrophilic polymers constituting 5.0 to 90 % and preferably 10 to 85 % of the layer weight; b) a second layer (2) adjacent to or superposed on the first layer, in which is carried the alfuzosine chlorhydrate, this layer being formed with hydrophilic polymers and other auxiliary substances, so as to give to the preparation suitable compressibility properties and to enable the release of the alfuzosine chlorhydrate in a predetermined lapse of time; c) and optionally a third layer (3) obtained by compression and applied on layer (2), generally consisting in particular of hydrophilic polymers which gel and/or swell and then can be optionally eroded and acting as a barrier modulating the release of the alfuzosine of layer (2), layer (3) being almost impermeable to the passage of the active substance. The invention is applicable to a pharmaceutical composition.
IPC 1-7
IPC 8 full level
A61K 9/20 (2006.01); A61K 9/24 (2006.01); A61K 9/22 (2006.01); A61K 31/505 (2006.01); A61K 31/517 (2006.01); A61P 13/08 (2006.01)
CPC (source: EP KR US)
A61K 9/2086 (2013.01 - EP US); A61K 31/505 (2013.01 - KR); A61K 31/517 (2013.01 - EP US); A61P 9/00 (2018.01 - EP); A61P 13/08 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9808515 A1 19980305; AP 1107 A 20020920; AP 9901470 A0 19990331; AR 009312 A1 20000412; AT E200864 T1 20010515; AU 4020197 A 19980319; AU 724490 B2 20000921; BG 103138 A 19990930; BG 63768 B1 20021229; BR 9713237 A 20000404; BR 9713237 B1 20090113; CA 2264250 A1 19980305; CA 2264250 C 20050705; CN 100335057 C 20070905; CN 1155382 C 20040630; CN 1228700 A 19990915; CN 1543954 A 20041110; CO 4920217 A1 20000529; CY 2284 B1 20030704; CZ 295066 B6 20050518; CZ 65599 A3 19990616; DE 69704712 D1 20010607; DE 69704712 T2 20011129; DK 0938318 T3 20010820; EE 03855 B1 20021015; EE 9900090 A 19991015; EP 0938318 A1 19990901; EP 0938318 B1 20010502; ES 2159400 T3 20011001; GR 3036291 T3 20011031; HK 1020875 A1 20000526; HU 228007 B1 20120828; HU P9903428 A2 20000228; HU P9903428 A3 20000428; IL 128146 A0 19991130; IL 128146 A 20010111; IS 2091 B 20060315; IS 4964 A 19990129; JP 2000514462 A 20001031; JP 3797388 B2 20060719; KR 100364328 B1 20021226; KR 20000035929 A 20000626; MX PA99001958 A 20050908; NO 326206 B1 20081020; NO 990944 D0 19990226; NO 990944 L 19990427; NZ 334018 A 19990629; OA 10983 A 20030304; PL 191546 B1 20060630; PL 331862 A1 19990816; PT 938318 E 20011030; RU 2183459 C2 20020620; SI 0938318 T1 20011231; SK 27099 A3 19991210; SK 284388 B6 20050204; TR 199900289 T2 20001221; TW 522023 B 20030301; UA 69374 C2 20040915; US 6149940 A 20001121
DOCDB simple family (application)
FR 9701515 W 19970822; AP 9901470 A 19970822; AR P970103839 A 19970825; AT 97937651 T 19970822; AU 4020197 A 19970822; BG 10313899 A 19990201; BR 9713237 A 19970822; CA 2264250 A 19970822; CN 200410042295 A 19970822; CN 97197558 A 19970822; CO 97049830 A 19970828; CY 0200038 A 20020515; CZ 65599 A 19970822; DE 69704712 T 19970822; DK 97937651 T 19970822; EE 9900090 A 19970822; EP 97937651 A 19970822; ES 97937651 T 19970822; GR 20010401141 T 20010726; HK 99105968 A 19991220; HU P9903428 A 19970822; IL 12814697 A 19970822; IS 4964 A 19990129; JP 51133198 A 19970822; KR 19997001666 A 19990227; MX 9901958 A 19970822; NO 990944 A 19990226; NZ 33401897 A 19970822; OA 9900042 A 19990226; PL 33186297 A 19970822; PT 97937651 T 19970822; RU 99105730 A 19970822; SI 9730158 T 19970822; SK 27099 A 19970822; TR 9900289 T 19970822; TW 86112274 A 19970826; UA 99020755 A 19970822; US 14758199 A 19990426