EP 0939757 A1 19990908 - NOVEL INTEGRIN RECEPTOR ANTAGONISTS
Title (en)
NOVEL INTEGRIN RECEPTOR ANTAGONISTS
Title (de)
NEUE INTEGRIN-REZEPTORANTAGONISTEN
Title (fr)
NOUVEAUX ANTAGONISTES DE RECEPTEURS D'INTEGRINES
Publication
Application
Priority
- US 9620523 W 19961218
- US 908895 P 19951222
- US 64666396 A 19960508
- US 2569996 P 19960909
Abstract (en)
[origin: WO9723480A1] This invention relates to novel heterocycles including 3-[1-[3-(imidazolin-2-ylamino)propyl]indazol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)propionic acid, which are useful as antagonists of the alpha v beta 3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiongenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
IPC 1-7
C07D 403/12; A61K 31/415; C07D 401/12; C07D 405/14; C07D 409/14; C07D 413/14; C07D 417/14
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/00 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/4184 (2006.01); A61K 31/42 (2006.01); A61K 31/422 (2006.01); A61K 31/425 (2006.01); A61K 31/427 (2006.01); A61K 31/435 (2006.01); A61K 31/4353 (2006.01); A61K 31/437 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4439 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/529 (2006.01); A61K 31/55 (2006.01); A61P 7/00 (2006.01); A61P 7/02 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); A61P 27/00 (2006.01); A61P 27/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 7/00 (2017.12); A61P 7/02 (2017.12); A61P 19/00 (2017.12); A61P 19/10 (2017.12); A61P 27/00 (2017.12); A61P 27/06 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 9723480A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9723480 A1 19970703; AU 1345697 A 19970717; CA 2240439 A1 19970703; EP 0939757 A1 19990908; HR P960611 A2 19980430; JP 2000501105 A 20000202
DOCDB simple family (application)
US 9620523 W 19961218; AU 1345697 A 19961218; CA 2240439 A 19961218; EP 96944984 A 19961218; HR P960611 A 19961220; JP 52384596 A 19961218