EP 0939900 A4 20030108 - DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES
Title (en)
DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES
Title (de)
NACHWEIS VON ANTAGONIST-ABHÄNGIGEN GPIIb/IIIa REZEPTOR-ANTIKÖRPERN
Title (fr)
DETECTION D'ANTICORPS DE RECEPTEUR GPIIb/IIIa DEPENDANT D'ANTAGONISTES
Publication
Application
Priority
- GB 9702822 A 19970212
- GB 9705856 A 19970321
- US 9720954 W 19971117
- US 3166196 P 19961121
- US 3546197 P 19970114
Abstract (en)
[origin: WO9822821A1] The present invention is a method for identifying a patient at risk to developing fibrinogen receptor antagonist-induced thrombocytopenia which comprises incubating patient plasma with a GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist complex to form a GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist:plasma antibody complex, incubating the GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist:plasma antibody complex with a secondary anti-human detectable antibody to form a GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist:plasma antibody:secondary anti-human detectable antibody complex, and detecting the presence of the secondary anti-human detectable antibody in the GPIIb/IIIa receptor:GPIIb/IIIa receptor antagonist:plasma antibody:secondary anti-human detectable antibody complex.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/86 (2006.01)
CPC (source: EP)
G01N 33/86 (2013.01); G01N 2333/70546 (2013.01)
Citation (search report)
- [X] US 4717654 A 19880105 - SAVOCA KENNETH V [US], et al
- [A] FR 2665769 A1 19920214 - SERBIO [FR]
- [X] VISENTIN G P ET AL: "DETECTION OF DRUG-DEPENDENT, PLATELET-REACTIVE ANTIBODIES BY ANTIGEN-CAPTURE ELISA AND FLOW CYTOMETRY", TRANSFUSION, AMERICAN ASSOCIATION OF BLOOD BANKS, BETHESDA, MD, US, vol. 30, no. 8, October 1990 (1990-10-01), pages 694 - 700, XP000983195, ISSN: 0041-1132
- [X] CURTIS BRIAN R ET AL: "Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex.", BLOOD, vol. 84, no. 1, 1994, pages 176 - 183, XP001029348, ISSN: 0006-4971
- [X] BEDNAR B ET AL: "DRUG-DEPENDENT ANTIBODIES AGAINST GPIIB/IIIA INDUCE THROMBOCYTOPENIA", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 94, no. 8, SUPPL 1, 15 October 1996 (1996-10-15), pages 571, XP001029709, ISSN: 0009-7322
- See references of WO 9822821A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9822821 A1 19980528; CA 2271684 A1 19980528; EP 0939900 A1 19990908; EP 0939900 A4 20030108; JP 2001504584 A 20010403
DOCDB simple family (application)
US 9720954 W 19971117; CA 2271684 A 19971117; EP 97947553 A 19971117; JP 52378398 A 19971117