Title (en)

DEVICES AND METHODS COMPRISING A SERUM ALBUMIN - TARGET ANTIGEN COMPLEX

Title (de)

GERÄTE UND VERFAHREN EINEN SERUMALBUMIN-ZIELARTIGEN KOMPLEX UMFASSEND

Title (fr)

DISPOSITIFS ET PROCEDES A BASE D'UN COMPLEXE CONSTITUE PAR DE L'ALBUMINE SERIQUE ET UN ANTIGENE CIBLE

Publication

EP 0939901 A1 19990908 (EN)

Application

EP 97911646 A 19971017

Priority

• US 9718194 W 19971017
• US 73091296 A 19961018
• US 85275697 A 19970507

Abstract (en)

[origin: WO9818006A1] Improved methods and compositions for the detection and diagnosis of disease utilizing a target antigen complexed with a serum albumin to provide a conformationally changed target antigen. Also, antibodies, including both IgM and IgG antibodies as well as all other forms of antibodies, specific for serum albumin and/or for the conformationally changed target antigens, as well as methods for purifying each using immunologic methods such as affinity columns. Enhanced methods and compositions comprising a target antigen complexed with a serum albumin for the induction of immune responses in an animal, as well as enhanced vaccination of such an animal. Further, a preferred buffer, TNSCN, comprised of Tris-HC1, NaC1, and NaSCN, typically at a pH of about 7.4 +/- 0.2.

IPC 1-7

G01N 33/543; G01N 33/532; G01N 33/58; G01N 33/569; G01N 33/68; G01N 33/576

IPC 8 full level

G01N 33/531 (2006.01); G01N 33/53 (2006.01); G01N 33/532 (2006.01); G01N 33/543 (2006.01); G01N 33/58 (2006.01)

CPC (source: EP)

G01N 33/532 (2013.01); G01N 33/54306 (2013.01); G01N 33/54353 (2013.01); G01N 33/58 (2013.01)

Citation (search report)

See references of WO 9818006A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9818006 A1 19980430; AU 4896497 A 19980515; CA 2269087 A1 19980430; EP 0939901 A1 19990908; JP 2001502803 A 20010227

DOCDB simple family (application)

US 9718194 W 19971017; AU 4896497 A 19971017; CA 2269087 A 19971017; EP 97911646 A 19971017; JP 51941798 A 19971017