EP 0941086 A1 19990915 - NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITOR COMPOUNDS, COMPOSITIONS AND THEIR USES
Title (en)
NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITOR COMPOUNDS, COMPOSITIONS AND THEIR USES
Title (de)
NITROSIERTE UND NITROSYLIERTE PHOSPHODIESTERASE HEMMENDE VERBINDUNGEN, ZUSAMMENSETZUNGEN UND IHRE VERWENDUNGEN
Title (fr)
COMPOSES NITROSES ET NITROSYLES INHIBITEURS DE LA PHOSPHODIESTERASE, COMPOSITIONS COMPRENANT CES COMPOSES ET UTILISATIONS CORRESPONDANTES
Publication
Application
Priority
- US 9719870 W 19971031
- US 74076496 A 19961101
Abstract (en)
[origin: WO9819672A1] Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydroxyl condensation), sulfur (sulfhydryl condensation), carbon and nitrogen. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of a phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO<+>) or nitroxyl (NO<->), or as the neutral species, nitric oxide (NO<.>) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a method for treating male impotence in humans by administering the compounds and compositions thereof.
IPC 1-7
A61K 31/165; A61K 31/38; A61K 31/40; A61K 31/415; A61K 31/425; A61K 31/44; A61K 31/47; A61K 31/50; A61K 31/505; C07D 207/24; C07D 487/04; C07D 405/14
IPC 8 full level
C07D 473/30 (2006.01); A61K 31/4015 (2006.01); A61K 31/4188 (2006.01); A61K 31/4375 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/4745 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/519 (2006.01); A61K 31/52 (2006.01); A61K 31/522 (2006.01); A61K 45/00 (2006.01); A61P 15/10 (2006.01); C07D 207/12 (2006.01); C07D 213/89 (2006.01); C07D 215/227 (2006.01); C07D 237/04 (2006.01); C07D 277/22 (2006.01); C07D 279/04 (2006.01); C07D 401/02 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 405/14 (2006.01); C07D 471/04 (2006.01); C07D 471/14 (2006.01); C07D 487/04 (2006.01); C07D 487/14 (2006.01)
CPC (source: EP)
A61P 15/10 (2017.12); C07D 405/14 (2013.01); C07D 487/04 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9819672 A1 19980514; AU 5196298 A 19980529; AU 722480 B2 20000803; CA 2270118 A1 19980514; EP 0941086 A1 19990915; EP 0941086 A4 20000712; JP 2001504457 A 20010403
DOCDB simple family (application)
US 9719870 W 19971031; AU 5196298 A 19971031; CA 2270118 A 19971031; EP 97946871 A 19971031; JP 52161698 A 19971031