Global Patent Index - EP 0941120 A4

EP 0941120 A4 20040818 - BRANCHED PEPTIDE LINKERS

Title (en)

BRANCHED PEPTIDE LINKERS

Title (de)

VERZWEIGTE PEPTIDLINKER

Title (fr)

SEQUENCES DE LIAISON PEPTIDIQUES RAMIFIEES

Publication

EP 0941120 A4 20040818 (EN)

Application

EP 97946428 A 19971031

Priority

  • US 9719851 W 19971031
  • US 3036796 P 19961105

Abstract (en)

[origin: WO9819705A1] Conjugates containing a targeting ligand, such as an antibody, a therapeutically active drug and a branched peptide linker. The branched peptide linker contains two or more amino acid moieties that provide an enzyme cleavage site. The number of drugs capable of being bonded to the branched linkers varies by a factor of two for each generation of branching.

IPC 1-7

A61K 47/48; C07K 5/06; C07K 5/10; C07K 5/08

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 38/27 (2006.01); A61K 38/46 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 5/00 (2006.01); C07K 5/02 (2006.01); C07K 5/06 (2006.01); C07K 5/065 (2006.01); C07K 5/068 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01)

CPC (source: EP)

A61K 47/641 (2017.07); A61K 47/65 (2017.07); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 5/0202 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 5/06078 (2013.01); C07K 5/06086 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [A] SHIH L B ET AL: "ANTHRACYCLINE IMMUNOCONJUGATES PREPARED BY A SITE-SPECIFIC LINKAGE VIA AN AMINODEXTRAN INTERMEDIATE CARRIER", CANCER RESEARCH, vol. 51, no. 16, 1991, pages 4192 - 4198, XP001181850, ISSN: 0008-5472
  • [A] WILLNER DAVID ET AL: "(6-Maleimidocaproyl)hydrazone of doxorubicin-A new derivative for the preparation of immunoconjugates of doxorubicin", BIOCONJUGATE CHEMISTRY, vol. 4, no. 6, 1993, pages 521 - 527, XP002284219, ISSN: 1043-1802
  • [A] KING H D ET AL: "Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates.", BIOCONJUGATE CHEMISTRY. UNITED STATES 1999 MAR-APR, vol. 10, no. 2, March 1999 (1999-03-01), pages 279 - 288, XP002284220, ISSN: 1043-1802
  • [A] DUBOWCHIK GENE M ET AL: "Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 11, 3 June 2002 (2002-06-03), pages 1529 - 1532, XP002284221, ISSN: 0960-894X
  • See references of WO 9819705A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9819705 A1 19980514; AU 5159798 A 19980529; CA 2264610 A1 19980514; EP 0941120 A1 19990915; EP 0941120 A4 20040818; JP 2001505194 A 20010417

DOCDB simple family (application)

US 9719851 W 19971031; AU 5159798 A 19971031; CA 2264610 A 19971031; EP 97946428 A 19971031; JP 52160698 A 19971031