EP 0941124 A1 19990915 - ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS FOR SELECTIVELY KILLING CANCER CELLS
Title (en)
ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS FOR SELECTIVELY KILLING CANCER CELLS
Title (de)
ANTISENSE-OLIGONUKLEOTID ZUSAMMENSTELLUNGEN ZUR GEZIELTEN TÖTUNG VON KREBSZELLEN
Title (fr)
COMPOSITIONS D'OLIGONUCLEOTIDES ANTISENS POUR TUER SELECTIVEMENT LES CELLULES CANCEREUSES
Publication
Application
Priority
US 9618795 W 19961121
Abstract (en)
[origin: CA2272341A1] The present invention relates to methods and compositions for the treatment of cancer using an oligonucleotide and an hydroxyl radical up-regulator. The oligonucleotide is characterized by its ability to down-regulate the path by which the cell repairs oxidative damage to its DNA. Thus, the oligonucleotide renders the tumor cells more susceptible to eradication upon exposure to the hydroxyl radical up-regulator administered substantially concomitantly with or subsequent to administration of the oligonucleotide. This novel treatment, preferentially inhibits the proliferation or kills malignant cells but not normal cells. Preferably, the oligonucleotide is antisense to the gene which encodes protein p53, although other antisense oligonucleotides can also be used. The invention also includes novel conjugates of the oligonucleotide and the hydroxyl up-regulator, as well as new oligonucleotides.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61K 51/00 (2006.01); A61K 51/06 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 1059197 A 19980610; AU 714393 B2 20000106; CA 2272341 A1 19980528; EP 0941124 A1 19990915; EP 0941124 A4 20041215
DOCDB simple family (application)
AU 1059197 A 19961121; CA 2272341 A 19961121; EP 96941450 A 19961121