EP 0941327 A1 19990915 - HUMAN G-PROTEIN RECEPTOR HCEGH45, A PACAP-LIKE (G-PROTEIN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-LIKE) RECEPTOR
Title (en)
HUMAN G-PROTEIN RECEPTOR HCEGH45, A PACAP-LIKE (G-PROTEIN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-LIKE) RECEPTOR
Title (de)
MENSCHLICHER G-PROTEIN REZEPTOR HCEGH45, EIN PACAP-ÄHNLICHER ¬G-PROTEIN ADENYLATZYKLASE AKTIVIERENDER POLYPEPTID-ÄHNLICH, AUS HYPOPHYSE REZEPTOR
Title (fr)
RECEPTEUR HCEGH45 HUMAIN DE PROTEINE G, UN RECEPTEUR DE TYPE PACAP (DE TYPE POLYPEPTIDE ACTIVATEUR D'ADENYLATE-CYCLASE HYPOPHISAIRE)
Publication
Application
Priority
- US 9720547 W 19971121
- US 3218696 P 19961202
Abstract (en)
[origin: WO9824900A1] A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); C07K 14/72 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9824900A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9824900 A1 19980611; AU 7625398 A 19980629; CA 2273198 A1 19980611; EP 0941327 A1 19990915; JP 2001505433 A 20010424
DOCDB simple family (application)
US 9720547 W 19971121; AU 7625398 A 19971121; CA 2273198 A 19971121; EP 97949398 A 19971121; JP 52559098 A 19971121