EP 0942756 A2 19990922 - OPTICAL DIAGNOSTIC AGENTS FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES BY MEANS OF NEAR INFRA-RED RADIATION (NIR RADIATION)
Title (en)
OPTICAL DIAGNOSTIC AGENTS FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES BY MEANS OF NEAR INFRA-RED RADIATION (NIR RADIATION)
Title (de)
OPTISCHE DIAGNOSTIKA ZUR DIAGNOSTIK NEURODEGENERATIVER KRANKHEITEN MITTELS NAHINFRAROT-STRAHLUNG (NIR-STRAHLUNG)
Title (fr)
AGENTS POUR ETABLIR UN DIAGNOSTIC PAR VOIE OPTIQUE DE MALADIES NEURODEGENERATIVES AU MOYEN D'UN RAYONNEMENT INFRAROUGE PROCHE
Publication
Application
Priority
- DE 9702559 W 19971029
- DE 19649971 A 19961119
Abstract (en)
[origin: DE19649971A1] The invention relates to compounds of formula (I): Fm(-A1) (-Bn) (-WO) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600 - 1200 nm; A is a beta -amyloid plaque binding biomolecule; B is a beta -amyloid plaque binding colorant; and W is a beta -amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo and in vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a contrasting agent in fluorescence and transillumination diagnosis in the NIR range. Diagnostic agents containing said components are also disclosed.
IPC 1-7
IPC 8 full level
C07D 231/22 (2006.01); A61K 49/00 (2006.01); C07D 209/14 (2006.01); C07D 277/60 (2006.01); C07D 277/64 (2006.01); C07H 5/06 (2006.01); C07H 15/26 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C08B 37/00 (2006.01); C09B 23/08 (2006.01); C09B 56/16 (2006.01); G01N 33/52 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61K 49/0032 (2013.01 - EP US); A61K 49/0052 (2013.01 - EP US); A61K 49/0054 (2013.01 - EP US); A61K 49/0056 (2013.01 - EP US); C07H 15/26 (2013.01 - EP US); C08B 37/0075 (2013.01 - EP US); C09B 23/086 (2013.01 - EP US); C09B 56/16 (2013.01 - EP US); G01N 33/52 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP US); G01N 2800/28 (2013.01 - EP US)
Citation (search report)
See references of WO 9822146A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19649971 A1 19980528; AU 7298598 A 19980610; CA 2272320 A1 19980528; CN 1237911 A 19991208; EP 0942756 A2 19990922; JP 2001506591 A 20010522; US 6329531 B1 20011211; WO 9822146 A2 19980528; WO 9822146 A3 19981015
DOCDB simple family (application)
DE 19649971 A 19961119; AU 7298598 A 19971029; CA 2272320 A 19971029; CN 97199895 A 19971029; DE 9702559 W 19971029; EP 97948710 A 19971029; JP 52305998 A 19971029; US 30817799 A 19991118