EP 0942969 A1 19990922 - METHOD FOR IDENTIFYING TRANSLATIONALLY REGULATED GENES
Title (en)
METHOD FOR IDENTIFYING TRANSLATIONALLY REGULATED GENES
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG VON GENEN WELCHE AUF DER STUFE DER TRANSLATION REGULIERT WERDEN
Title (fr)
PROCEDE D'IDENTIFICATION DES GENES REGULES PAR TRADUCTION
Publication
Application
Priority
- US 9720831 W 19971112
- US 74813096 A 19961112
- US 94358697 A 19971003
Abstract (en)
[origin: WO9821321A1] A method for identifying translationally regulated genes includes selectively stimulating translation of an unknown target mRNA with a stress inducing element wherein the target mRNA is part of a larger sample of mRNA. The mRNA sample is divided into pools of translated and untranslated mRNA which are differentially analyzed to identify genes that are translationally regulated by the stress inducing element. A method for identifying gene sequences coding for internal ribosome entry sites includes inhibiting 5'cap-dependent mRNA translation in a cell, collecting a pool of mRNA from the cells, and differentially analyzing the pool of mRNA to identify genes with sequences coding for internal ribosome entry sites.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
C12N 15/1051 (2013.01); C12Q 1/6809 (2013.01)
Citation (search report)
See references of WO 9821321A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU
DOCDB simple family (publication)
WO 9821321 A1 19980522; AU 5258098 A 19980603; CA 2271068 A1 19980522; EP 0942969 A1 19990922; IL 129872 A0 20000229; IL 129872 A 20060410; JP 2002515754 A 20020528
DOCDB simple family (application)
US 9720831 W 19971112; AU 5258098 A 19971112; CA 2271068 A 19971112; EP 97947522 A 19971112; IL 12987297 A 19971112; IL 12987299 A 19990510; JP 52285498 A 19971112